| structure name | ZINC FINGER DOMAIN OF WT1(-KTS FORM) WITH 12+1MER OLIGONUCLEOTIDE WITH 3' TRIPLET TGT (Wilms tumor protein) |
| reference | Horton et al. 'Nucleic 46 3864 2018 |
| source | Homo sapiens |
| experiment | X-ray (resolution=1.55, R-factor=0.193) |
| structural superfamily | beta-beta-alpha zinc fingers; |
| sequence family | Zinc finger, C2H2 type; |
| redundant complexes | 2jp9 2jpa 6b0p 6blw |
| reference complex | 2jpa_A |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | KHRDQRRSDHTRDER |
Estimated binding specificities ?
| readout + contact |  |
A | 1 0 0 0 0 0 0 96 0 0 19 C | 19 96 0 0 0 0 0 0 0 0 20 G | 76 0 96 0 96 96 96 0 96 0 38 T | 0 0 0 96 0 0 0 0 0 96 19scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: WILMS TUMOR SUPPRESSOR | ||
| GCGGGGGCG | PubMed | 6b0o_A(5.33e-05), 6b0p_A(1.11e-05), 2jp9_A(1.32e-13), ... (total=4) |
| CGCCCCCGC | PubMed | 6b0o_A(5.33e-05), 6b0p_A(1.11e-05), 2jp9_A(1.32e-13), ... (total=4) |
| CCCTC | PubMed | 6b0p_A(1.37e-05), 6blw_A(3.68e-06) |
| TCCTCCTCCTCCTCTCC | PubMed | 6b0p_A(1.19e-02) |
| GCGGGGGAG | PubMed | 6b0o_A(6.68e-09), 6b0p_A(7.35e-10), 2jp9_A(1.85e-08), ... (total=5) |
| GGGCG | PubMed | 2jp9_A(2.06e-05), 2jpa_A(1.71e-05) |
| GGAGAGGGAGGATC | PubMed | 6b0o_A(4.19e-03), 6b0p_A(2.70e-06), 6blw_A(5.92e-04) |
Dendrogram of similar interfaces ?
matrix format--DC--SCQGKTTTAT--SCSC----DC--SGATRARG----RG--DCNA------ L +-----------6ml4_A +--------------6 --DC--YCKGRG--QA----TC----RC--SCDC--VT------------------ L ! +-----------5k5i_A ! --AT--YC------RA----NC------ATSGDC--KG----DCPTSGSARTKG-- L ! +-------------------------2gli_A ! ! --NG--SGHGRG--DA--SCHGRGRGDC--SCNA--------NCKTSAHG--RG-- L -14 ! +5ei9_F ! ! +---------1 --CT--STQTLTITST--STHTRG--RG----EA--RA------TTTGEC--RG-- L ! ! +--------4 +5v3j_F ! ! ! ! --EC--SGKGRG--DG--YCKGRG--QA----TC--------RA--SCDC--VT-- L ! ! +--9 +---------5k5h_A ! ! ! ! FT----KAYT----WT--WTSTET--FTVASGDC--SARG---------------- L +-13 ! ! +----------6jnm_A ! ! +-------5 ------------------------RGST--YGYC--------QC--TGSTRGYT-- L ! +-11 +----------4is1_C ! ! ! --RGSTDTEGRG--RGSGDCHGTT--RG--DAEG--RG------------------ L ! ! ! +4x9j_A ! ! ! +----------------2 ------------NGKT--WTKG--------HTHG--RG--TGTT--ACNA--KGRG L ! ! +----8 +1tf3_A ! ! ! --------------------YG----WT--WTST--ET----FTVASGDCSART-- L +--12 +----------------6a57_A ! --EC--SCKGRG----TCYCKARG--QA----TC--------RA--SCDC--VT-- L ! +-----5yeg_A ! +----------3 ------SA--MT--VT----NARG------ETTG--------YG--ST-------- ! +----7 +-----6e94_A ! ! ! --------------------------QA----TC--RG----RG--YCRT------ L +-10 +----------------7txc_E ! ------------QT--AG--KGRG--RG--DCKG---------------------- L +---------------------7n5w_A |
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updated Thu Sep 12 22:48:59 2024