interface graph thumbnail
legend  pdf

structure nameHUMAN APE1 SUBSTRATE COMPLEX WITH AN G/G MISMATCH ADJACENT THE THF
(DNA-apurinic or apyrimidinic site lyase)
referenceFreudenthal et al. 'Acta 74 760 2018
sourceHomo sapiens
experimentX-ray (resolution=1.84, R-factor=0.172)
structural superfamilyDNase I-like;
sequence familyEndonuclease/Exonuclease/phosphatase fa;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDQKYNYMM

Estimated binding specificities ?

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# IC=2.423 IC/col=0.404 n_of_columns=6 specificity:   
A |  16   9  24   0  22   8
C |  45   9  24   0  30   8
G |  16  69  24  96  22  70
T |  19   9  24   0  22  10
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updated Tue Dec 17 03:29:25 2024