interface graph thumbnail
legend  pdf

structure nameHUMAN APE1 SUBSTRATE COMPLEX WITH AN G/G MISMATCH ADJACENT THE THF
(DNA-apurinic or apyrimidinic site lyase)
referenceFreudenthal et al. 'Acta 74 760 2018
sourceHomo sapiens
experimentX-ray (resolution=1.84, R-factor=0.172)
structural superfamilyDNase I-like;
sequence familyEndonuclease/Exonuclease/phosphatase fa;
reference complex6bow_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDQKYNYMM

Estimated binding specificities ?

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# IC=3.101 IC/col=0.517 n_of_columns=6 specificity:   
A |   0  24   0  24  13  13
C |  96  24   0  24  54  13
G |   0  24  96  24  16  54
T |   0  24   0  24  13  16
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updated Thu Sep 12 22:53:06 2024