interface graph thumbnail
legend  pdf

structure nameHUMAN APE1 SUBSTRATE COMPLEX WITH AN C/C MISMATCH ADJACENT THE THF
(DNA-apurinic or apyrimidinic site lyase)
referenceFreudenthal et al. 'Acta 74 760 2018
sourceHomo sapiens
experimentX-ray (resolution=2.30, R-factor=0.204)
structural superfamilyDNase I-like;
sequence familyEndonuclease/Exonuclease/phosphatase fa;
reference complex6bow_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDKRNNYMM

Estimated binding specificities ?

contactlogo
# IC=3.101 IC/col=0.517 n_of_columns=6 specificity:   
A |  13  24   0  24   0  13
C |  54  24  96  24  96  13
G |  13  24   0  24   0  54
T |  16  24   0  24   0  16
scan!

home
updated Fri Jan 9 05:37:01 2026