interface graph thumbnail
legend  pdf

structure nameHUMAN APE1 SUBSTRATE COMPLEX WITH AN C/C MISMATCH ADJACENT THE THF
(DNA-apurinic or apyrimidinic site lyase)
referenceFreudenthal et al. 'Acta 74 760 2018
sourceHomo sapiens
experimentX-ray (resolution=2.30, R-factor=0.204)
structural superfamilyDNase I-like;
sequence familyEndonuclease/Exonuclease/phosphatase fa;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDKRNNYMM

Estimated binding specificities ?

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# IC=3.101 IC/col=0.517 n_of_columns=6 specificity:   
A |  16   0  24   0  24  13
C |  54   0  24  96  24  13
G |  13  96  24   0  24  54
T |  13   0  24   0  24  16
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updated Tue Dec 17 03:29:44 2024