6brr_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DNMT3A (R836A)-DNMT3L IN COMPLEX WITH DNA CONTAINING TWO CPG SITES
reference	Zhang et al. Nature 554 387 2018
source	HOMO SAPIENS
experiment	X-ray (resolution=2.97, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6pa7_K
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6brr_A interface=88,89,90,91,207,208,209,210,211, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTTASNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrlarqrllgrswsvpvirhlfaplkeyfacv > 6brr_D interface=88,89,90,91,207,208,209,210,211,256, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTTASNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrLarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVNPTTASN/IVNPTTASNL

Estimated binding specificities ?

contact

# IC=9.490 IC/col=0.593 n_of_columns=16

specificity:

A |   4   0  14   5   5   1  24  24  24  24  24   1  66  24   0   0
C |   5   0   4   4  83   0  24  24  24  24  24   4  12  24  96  96
G |  83  96   8   4   4   4  24  24  24  24  24  87   8  24   0   0
T |   4   0  70  83   4  91  24  24  24  24  24   4  10  24   0   0

scan!

home
updated Thu Jun 25 12:32:36 2026