6brr_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DNMT3A (R836A)-DNMT3L IN COMPLEX WITH DNA CONTAINING TWO CPG SITES
reference	Zhang et al. Nature 554 387 2018
source	HOMO SAPIENS
experiment	X-ray (resolution=2.97, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6w8b_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6brr_A interface=88,89,90,91,207,208,209,210,211, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTTASNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrlarqrllgrswsvpvirhlfaplkeyfacv > 6brr_D interface=88,89,90,91,207,208,209,210,211,256, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTTASNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmsrLarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVNPTTASN/IVNPTTASNL

Estimated binding specificities ?

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# IC=10.845 IC/col=0.678 n_of_columns=16

specificity:

A |   0   0  24  14   0  10  24  24  24  24  92   3  88  56   0   0
C |   0   0  24  10  96  16  24  24  24  24   0   2   5  16  96  96
G |  96  96  24  14   0   3  24  24  24  24   4  88   3  10   0   0
T |   0   0  24  58   0  67  24  24  24  24   0   3   0  14   0   0

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updated Wed Jul 30 15:31:54 2025