6fwk_B : 3D-footprint complex

structure name	THE CRYSTAL STRUCTURE OF POL2CORE-M644G IN COMPLEX WITH DNA AND AN INCOMING NUCLEOTIDE (DNA polymerase epsilon catalytic subunit A)
reference	Johansson et al. 'Nat 10 373 2019
source	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) / Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
experiment	X-ray (resolution=2.50, R-factor=0.225)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
sequence family	DNA polymerase family B, exonuclease do; DNA polymerase family B 1024;
reference complex	4m8o_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6fwk_B interface=881,902, yalsaqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsqenqgisgvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiirkedltmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynvvdakhliedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettkpplkfpdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnendevallqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykssycshmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysvsdavatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkhtdpierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfsvevenkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasgypnimttnrlqpdsiktcarklkwawrgeffpskmdeynmikralqnetfpnltfdelsyadqvihikkrlteysrkvseivereaivcqrenpfyvdtvksfrdrryefkglaktwkgnlskidpsdkhardeakkmivlydslqlahkvilnsfygyvmrkgsrwysmemagitcltgatiiqmaralvervgrpleldtdgiwcilpksfpetyfftlengkklylsypcsmlnyrvhqkftnhqyqelkdplnyiyethsentiffevdgpykamilpsskeegkgikKryavfnedgslaelkgfelkRrgelqliknfqsdifkvflegdtlegcysavasvcnrwldvldshglmlededlvslicenrsmsktlkeyegqkstsittarrlgdflgedmvkdkglqckyiisskpfnapvteraipvaifsadipikrsflrrwtldpsledldirtiidwgyyrerlgsaiqkiitipaalqgvsnpvprvehpdwlkrkia
interface signature	KR

Estimated binding specificities ?

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# IC=2.746 IC/col=0.687 n_of_columns=4

specificity:

A |  75  96  14   7
C |   7   0  53   7
G |   7   0  22  73
T |   7   0   7   9

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updated Fri Jan 9 06:23:13 2026