6g0a_A : 3D-footprint complex

structure name	THE CRYSTAL STRUCTURE OF THE POL2 CATALYTIC DOMAIN OF DNA POLYMERASE EPSILON CARRYING A P301R SUBSTITUTION. (DNA polymerase epsilon catalytic subunit A)
reference	Johansson et al. 'Nat 10 373 2019
source	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) / Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
experiment	X-ray (resolution=2.62, R-factor=0.226)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
sequence family	DNA polymerase family B, exonuclease do; DNA polymerase family B 839;
reference complex	4m8o_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6g0a_A interface=885,906, nnyalsaqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsqetnqgisgvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiirkedltmdnhllglqktliklsfvnsnqlfearkllrpilqdnarniynvdakhliedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettkpplkfrdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnendevallqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykssycshmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysvsdavatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkhtdpierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfsvevenkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasmypnimttnrlqpdsikaertcarklkwawrgeffpskmdeynmikralqnetfpnkkkvltfdelsyadqvihikkrlteysrkvyhrvkvseivereaivcqrenpfyvdtvksfrdrryefkglaktwkgnlskhardeakkmivlydslqlahkvilnsfygyvmrkgsrwysmemagitcltgatiiqmaralvervgrpleldtdgiwcilpksfpetyfftlengkklylsypcsmlnyrvhqkftnhqyqelkdplnyiyethsentiffevdgpykamilpsskeegkgikKryavfnedgslaelkgfelkRrgelqliknfqsdifkvflegdtlegcysavasvcnrwldvldshglmlededlvslicenrsmsktlkeyegqkstsittarrlgdflgedmvkdkglqckyiisskpfnapvteraipvaifsadipikrsflrrwtldpsledldirtiidwgyyrerlgsaiqkiitipaalqgvsnpvprvehpdwlkrkiat
interface signature	KR

Estimated binding specificities ?

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# IC=2.589 IC/col=0.647 n_of_columns=4

specificity:

A |  69  72   9   8
C |  11   8  87   8
G |   8   8   0  72
T |   8   8   0   8

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updated Thu Sep 12 23:27:42 2024