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legend  pdf

structure nameTHE CRYSTAL STRUCTURE OF THE POL2 CATALYTIC DOMAIN OF DNA POLYMERASE EPSILON CARRYING A P301R SUBSTITUTION.
(DNA polymerase epsilon catalytic subunit A)
referenceJohansson et al. 'Nat 10 373 2019
sourceSaccharomyces cerevisiae (strain ATCC 204508 / S288c) / Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
experimentX-ray (resolution=2.65, R-factor=0.232)
structural superfamilyDNA/RNA polymerases;Ribonuclease H-like;
sequence familyDNA polymerase family B, exonuclease do; DNA polymerase family B 916;
reference complex4m8o_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKR

Estimated binding specificities ?

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# IC=2.295 IC/col=0.574 n_of_columns=4 specificity:   
A |  73  73   7   7
C |   7   7  75   7
G |   7   7   7  73
T |   9   9   7   9
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updated Sat Aug 2 11:26:07 2025