6i8a_A : 3D-footprint complex

structure name	THE CRYSTAL STRUCTURE OF THE POL2 CATALYTIC DOMAIN OF DNA POLYMERASE EPSILON CARRYING A P301R SUBSTITUTION. (DNA polymerase epsilon catalytic subunit A)
reference	Johansson et al. 'Nat 10 373 2019
source	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) / Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
experiment	X-ray (resolution=2.65, R-factor=0.232)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
sequence family	DNA polymerase family B, exonuclease do; DNA polymerase family B 916;
reference complex	4m8o_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6i8a_A interface=889,910, alsaqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsqenqgisgvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiirkedltmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynvdakhliedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettkpplkfrdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnendevallqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykssycshmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysvsdavatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkhtdpierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfsvevenkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasmypnimttnrlqpdsikaetcarklkwawrgeffpskmdeynmikralqnetfpnknltfdelsyadqvihikkrlteysrkvyhrvkvseivereaivcqrenpfyvdtvksfrdrryefkglaktwkgnlskidpsdkhardeakkmivlydslqlahkvilnsfygyvmrkgsrwysmemagitcltgatiiqmaralvervgrpleldtdgiwcilpksfpetyfftlengkklylsypcsmlnyrvhqkftnhqyqelkdplnyiyethsentiffevdgpykamilpsskeegkgikKryavfnedgslaelkgfelkRrgelqliknfqsdifkvflegdtlegcysavasvcnrwldvldshglmlededlvslicenrsmsktlkeyegqkstsittarrlgdflgedmvkdkglqckyiisskpfnapvteraipvaifsadipikrsflrrwtldpsledldirtiidwgyyrerlgsaiqkiitipaalqgvsnpvprvehpdwlkrkia
interface signature	KR

Estimated binding specificities ?

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# IC=2.730 IC/col=0.682 n_of_columns=4

specificity:

A |   7   0   7   7
C |  73   0   7  14
G |   9  96   7  24
T |   7   0  75  51

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updated Sun Jun 28 16:08:25 2026