6kdb_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF HUMAN DNMT3B-DNMT3L IN COMPLEX WITH DNA CONTAINING CPGPT SITE
reference	Chen et al. 'Nucleic 48 3949 2020
source	HOMO SAPIENS
experiment	X-ray (resolution=2.86, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6kdb_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6kdb_A interface=87,88,90,92,206,208,210, mrrrpirvlslfdgiatgylvlkelgikvgkyvasevceesiavgtvkhegnikyvndvrnitkknieewgpfdlviggspcndlsNVnPaRkglyegtgrlffefyhllnysrpkegddrpffwmfenvvamkvgdkrdisrflecnpvmidaikvsaahraryfwgnlpgmnrpviaskndklelqdcleynriaklkkvqtiTtKsNsikqgknqlfpvvmngkedvlwctelerifgfpvhytdvsnmgrgarqkllgrswsvpvirhlfaplkdyface > 6kdb_D interface=87,88,89,90,206,210, mrrrpirvlslfdgiatgylvlkelgikvgkyvasevceesiavgtvkhegnikyvndvrnitkknieewgpfdlviggspcndlsNVNParkglyegtgrlffefyhllnysrpkegddrpffwmfenvvamkvgdkrdisrflecnpvmidaikvsaahraryfwgnlpgmnrpviaskndklelqdcleynriaklkkvqtiTtksNsikqgknqlfpvvmngkedvlwctelerifgfpvhytdvsnmgrgarqkllgrswsvpvirhlfaplkdyface
interface signature	NVPRTKN/NVNPTN

Estimated binding specificities ?

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# IC=5.766 IC/col=0.360 n_of_columns=16

specificity:

A |  13   0   0  24  24  24  24  24  24  24  24  24  24   0   0  54
C |  16   0   0  24  24  24  24  24  24  24  24  24  24  96  96  13
G |  13  96  96  24  24  24  24  24  24  24  24  24  24   0   0  16
T |  54   0   0  24  24  24  24  24  24  24  24  24  24   0   0  13

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updated Tue Sep 10 15:21:53 2024