6m0x_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF STREPTOCOCCUS THERMOPHILUS CAS9 IN COMPLEX WITH AGGA PAM (CRISPR-associated endonuclease Cas9 1)
reference	Zhang et al. 'Nat ? ? 2020
source	Streptococcus thermophilus LMD-9
experiment	X-ray (resolution=2.56, R-factor=0.227)
redundant complexes	6m0v 6rjd 6rjg 6m0w 6rj9 6rja
reference complex	6rjd_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6m0x_A interface=625,735,872,959,960,963,966,993,995,997, lvlgldigigsvgvgilnkvtgeiihknsrifpaaqaennlvrrtnrqgrrlarrkkhrrvrlnrlfeesglitdftkisinlnpyqlrvkgltdelsneelfialknmvkhrgisyktpgqiqleryqtygqlrgdftvekdgkkhrlinvfptsayrsealrilqtqqefnpqitdefinryleiltgkrkyyhgpgneksrtdygryrtsgetldnifgiligkctfypdefraakasytaqefnllndlnnltvptklskeqknqiinyvknekamgpaklfkyiaklldvadikgyridksgkaeihtfeayrkmktletldieqmdretldklayvltlnteregiqealehefadgsfsqkqvdelvqfrkanssifgkgwhnfsvklmmelipelyetseeqmtiltrlgyidekllteeiynpvvaksvrqaikivnaaikeygdfdniviemaretneddekkaiqkiqkankdekdaamlkaanqyngkaelphsvfhghkqlatkirlwhqqgerclytgktisihdlinnsnqfevdailplsitfddslankvlvyatanqekgqrtpyqaldsmddawsfrelkafvresktlsnkkkeyllteediskFdviernlvdtryasrvvlnalqehfrahkidtkvsvvrgqftsqlrrhwgiektrdtyhhhavdaliiaassqlnlpyqhfvdtlkskefedsilfsyqvdskfnrkisDatiyatrqakvgkdkadetyvlgkikdiytqdgydafmkiykkdkskflmyrhdpqtfekviepilenypnkqinekgkevpcnpflkykeehgyirkyskkgngpeikslkyydsklgnhiditpkdsnnkvvlqSvspwradvyfnkttgkyeilglkyadlqfekgtgtykisqekyndikkkegvdsdsefkftlykndlllvkdtetkeqqlfrflsrTMpkQkhYvelkpydkqkfeggealikvlgnvanSgQcKkglgksnisiykvrtdvlgnqhiiknegdkpkldf
interface signature	FDSTMQYSQK

Estimated binding specificities ?

readout + contact

# IC=7.580 IC/col=0.947 n_of_columns=8

specificity:

A |   7   7   9   7   0   0   0   0
C |   7  73   7  73  96   0   0   0
G |  73   9   7   7   0   0   0   0
T |   9   7  73   9   0  96  96  96

scan!

Dendrogram of similar interfaces ?

matrix format

  
  ----MT--TGNG--------------KGDG--DC--SC----RGYG--------   L                       +---------6je3_A    
                                                                              +----2 
  ----LGNT----------------------TA----SATT--ST------KTSG   L   +--------------3    +---------5x2h_A    
                                                               !              ! 
  RARC------------------------EA----EC----KGRA--RGRG----   L   !              +--------------6wbr_A    
                                                             --5 
  ------------STVTMCKGDCRGTA----------------------------   L   !             +---------------1iv6_A    
                                                               +-------------4 
  --------------VT--KGDCRGTA----------------------------   L                 !             +-7c4p_A    
                                                                             +-------------1 
  ------------STVC--KGDCRG------------------------------   L                               +-1w0t_A

home
updated Tue Dec 17 05:37:37 2024