6puy_ABC : 3D-footprint complex

structure name	STRUCTURE OF HIV CLEAVED SYNAPTIC COMPLEX (CSC) INTASOME BOUND WITH MAGNESIUM AND INSTI XZ426 (COMPOUND 4D)
reference	Jozwik et al. Science 367 810 2020
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	DNA-binding domain of retroviral integrase;
reference complex	6puy_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6puy_A interface=51,146,152,153,156, fldgidkaqeehekyhsnwramasdfnlppvvakeivascdkcqlkgeamHgqvdcspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtdngsnftsttvkaacwwagikqefgipynpQsqgviESmnKelkkiigqvrdqaehlktavqmavfihnfkrkggiggysagerivdiiatdiqtkelqkqitkiqnfrvyyrkgpakllwkgegavviqdnsdikvvprrkakii > 6puy_B interface=234, fldgidkaqeehekyhsnwramasdfnlppvvakeivascdkcspgiwqldcthlegkvilvavhvasgyieaevipaetgqetayfllklagrwpvktvhtdngsnftsttvkaacwwagikqefgviesmnkelkkiigqvrdqaehlktavqmavfihnfkrkggiggysagerivdiiatdiqtkelqkqitkiqnfrvyyrwkgpakllwkgegavviqdnsdikvvpRrkakiird > 6puy_C interface= elqkqitkiqnfrvyyrdsrdpvwkgpakllwkgegavviqdnsdikvvprrkakiirdygkqmag
interface signature	HQESK/R/

Estimated binding specificities ?

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# IC=3.101 IC/col=0.207 n_of_columns=15

specificity:

A |  13  24  24  24  24  24  24  24  24  24  24  24  54   0   0
C |  13  24  24  24  24  24  24  24  24  24  24  24  13   0  96
G |  54  24  24  24  24  24  24  24  24  24  24  24  16  96   0
T |  16  24  24  24  24  24  24  24  24  24  24  24  13   0   0

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updated Thu Jul 31 00:06:34 2025