6tbz_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE MH1 DOMAIN OF SMAD5-SMAD3 CHIMERA CONSTRUCT BOUND TO THE GGCGC SITE (MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5)
reference	Macias et al. 'Comput 19 632 2021
source	HOMO SAPIENS
experiment	X-ray (resolution=1.78, R-factor=0.193)
structural superfamily	SMAD MH1 domain;
sequence family	MH1 domain;
redundant complexes	6tce 6fzs
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6tbz_A interface=65,67,69,74, spavkrllgwkqgeqngqeekwaekavdalvkklkkkkgameelekalsspgqpskcvtiprslDgRlQvshrKglphviycrvwrwpdlqshhelkpldicefpfgskqkevcinpyhykrvespv
interface signature	DRQK

Estimated binding specificities ?

readout + contact

# IC=1.728 IC/col=0.432 n_of_columns=4

specificity:

A |   7   8  18   5
C |  72   9  41  81
G |   8  61  16   5
T |   9  18  21   5

scan!

Dendrogram of similar interfaces ?

matrix format

  
  DCRGQC--KG   L                             +6tbz_A    
                                   +---------3 
  --RGQC--KG   L                   !         +5od6_A    
                           +-------5 
  DCRGQC--KG   L           !       !         +6fzt_A    
                           !       +---------2 
  --RGQAHTKG   L   +-------6                 +5x6g_A    
                   !       ! 
  --RGQA--KA   L   !       !                +6h3r_A    
                   !       +----------------4 
  ----QC--KG     --7                        ! +5mey_A    
                   !                        +-1 
  --RGQC--KG   L   !                          +5nm9_A    
                   ! 
  DCRGQC--KG   L   +-------------------------6zmn_B

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updated Tue Dec 17 07:10:21 2024