interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE MH1 DOMAIN OF SMAD5-SMAD3 CHIMERA CONSTRUCT BOUND TO THE GGCGC SITE
(MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 5)
referenceMacias et al. 'Comput 19 632 2021
sourceHOMO SAPIENS
experimentX-ray (resolution=1.78, R-factor=0.193)
structural superfamilySMAD MH1 domain;
sequence familyMH1 domain;
redundant complexes6tce 6fzs
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDRQK

Estimated binding specificities ?

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# IC=1.703 IC/col=0.426 n_of_columns=4 specificity:   
A |   5  18  16   6
C |   6  16  60   9
G |  79  39  11  75
T |   6  23   9   6
scan!

Dendrogram of similar interfaces ?

matrix format
  
  DCRGQC--KG   L                             +6tbz_A    
                                   +---------3 
  --RGQC--KG   L                   !         +5od6_A    
                           +-------5 
  DCRGQC--KG   L           !       !         +6fzt_A    
                           !       +---------2 
  --RGQAHTKG   L   +-------6                 +5x6g_A    
                   !       ! 
  --RGQA--KA   L   !       !                +6h3r_A    
                   !       +----------------4 
  ----QC--KG     --7                        ! +5mey_A    
                   !                        +-1 
  --RGQC--KG   L   !                          +5nm9_A    
                   ! 
  DCRGQC--KG   L   +-------------------------6zmn_B

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updated Fri Sep 13 02:13:41 2024