6u8v_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DNMT3B-DNMT3L IN COMPLEX WITH CPGPT DNA
reference	Zhang et al. 'Nat 11 3355 2020
source	HOMO SAPIENS
experiment	X-ray (resolution=3.00, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6kdb_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6u8v_A interface=94,95,97,213,215,216,217, lypaipaarrrpirvlslfdgiatgylvlkelgikvgkyvasevceesiavgtvkhegnikyvndvrnitkknieewgpfdlviggspcndlsNVnParkglyegtgrlffefyhllnysrpkegddrpffwmfenvvamkvgdkrdisrflecnpvmidaikvsaahraryfwgnlpgmnrpviaskndklelqdcleynriaklkkvqtiTtKSNsikqgknqlfpvvmngkedvlwctelerifgfpvhytdvsnmgrgarqkllgrswsvpvirhlfaplkdyface > 6u8v_D interface=94,95,97,215,216,217, lypaipaarrrpirvlslfdgiatgylvlkelgikvgkyvasevceesiavgtvkhegnikyvndvrnitkknieewgpfdlviggspcndlsNVnParkglyegtgrlffefyhllnysrpkegddrpffwmfenvvamkvgdkrdisrflecnpvmidaikvsaahraryfwgnlpgmnrpviaskndklelqdcleynriaklkkvqtittKSNsikqgknqlfpvvmngkedvlwctelerifgfpvhytdvsnmgrgarqkllgrswsvpvirhlfaplkdyface
interface signature	NVPTKSN/NVPKSN

Estimated binding specificities ?

readout + contact

# IC=9.900 IC/col=0.619 n_of_columns=16

specificity:

A |   0   0   5   0   5  24  24  24  24  24  24  11  96  79   0   5
C |   0   0   5   0  67  24  24  24  24  24  24  11   0   7  96  86
G |  96  96   5   0  13  24  24  24  24  24  24  63   0   5   0   5
T |   0   0  81  96  11  24  24  24  24  24  24  11   0   5   0   0

scan!

home
updated Tue Jan 6 14:06:49 2026