6u8x_AD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DNMT3B-DNMT3L IN COMPLEX WITH CPAPG DNA
reference	Song et al. 'Nat 11 3355 2020
source	HOMO SAPIENS
experiment	X-ray (resolution=2.95, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6kdb_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6u8x_A interface=94,95,97,215,216,217, lypaipaarrrpirvlslfdgiatgylvlkelgikvgkyvasevceesiavgtvkhegnikyvndvrnitkknieewgpfdlviggspcndlsNVnParkglyegtgrlffefyhllnysrpkegddrpffwmfenvvamkvgdkrdisrflecnpvmidaikvsaahraryfwgnlpgmnrpviaskndklelqdcleynriaklkkvqtittKSNsikqgknqlfpvvmngkedvlwctelerifgfpvhytdvsnmgrgarqkllgrswsvpvirhlfaplkdyface > 6u8x_D interface=94,95,97,215,216,217, lypaipaarrrpirvlslfdgiatgylvlkelgikvgkyvasevceesiavgtvkhegnikyvndvrnitkknieewgpfdlviggspcndlsNVnParkglyegtgrlffefyhllnysrpkegddrpffwmfenvvamkvgdkrdisrflecnpvmidaikvsaahraryfwgnlpgmnrpviaskndklelqdcleynriaklkkvqtittKSNsikqgknqlfpvvmngkedvlwctelerifgfpvhytdvsnmgrgarqkllgrswsvpvirhlfaplkdyface
interface signature	NVPKSN/NVPKSN

Estimated binding specificities ?

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# IC=7.625 IC/col=0.477 n_of_columns=16

specificity:

A |   7  96   0   7  24  24  24  24  24  24  24  24  75   0   0   7
C |   7   0   0   9  24  24  24  24  24  24  24  24   7  96   0  73
G |  73   0  96   7  24  24  24  24  24  24  24  24   7   0   0   9
T |   9   0   0  73  24  24  24  24  24  24  24  24   7   0  96   7

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updated Tue Sep 10 21:26:50 2024