6u9q_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE ANALYSIS OF DNA-BCL11A ZNF DOMAIN COMPLEX (B-cell lymphomaleukemia 11A)
reference	Dhe-Paganon et al. 'To ? ? ?
source	Homo sapiens
experiment	X-ray (resolution=1.83, R-factor=0.176)
structural superfamily	beta-beta-alpha zinc fingers;
sequence family	Zinc finger, C2H2 type;
redundant complexes	6ki6_B 8tlo_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6u9q_A interface=17,19,20,23,45,46,47,48,51,81, egrrsdtceycgkvfkNcSNltVhrrshtgerpykcelcnyacaQSSKltRhmkthgqvgkdvykceickmpfsvystleKhmkkwhsd
interface signature	NSNVQSSKRK

Estimated binding specificities ?

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# IC=5.524 IC/col=0.690 n_of_columns=8

specificity:

A |  18  11   0  25  87   5   1  56
C |  40  11   0   3   3  83  91  14
G |  18   9   1  68   3   4   3  12
T |  20  65  95   0   3   4   1  14

scan!

Dendrogram of similar interfaces ?

matrix format

  
  NT--STNAVT--QTSTSGKG--RGKG   L                +------------6u9q_A    
                                            +---2 
  ------YG----WT--WTST--ET--   L            !   +------------6a57_A    
                                   +--------3 
  DCTCYCKGRG--QA----TC------   L   !        !    +-----------5und_A    
                                 --4        +----1 
  DG--YCKGRGTCQA----TC------   L   !             +-----------5t0u_A    
                                   ! 
  QA--TTNA--STQAQTATSTNTAT--   L   +-------------------------1g2f_F

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updated Fri Sep 13 23:48:51 2024