interface graph thumbnail
legend  pdf

structure nameAPE1 Y269A PHOSPHOROTHIOATE SUBSTRATE COMPLEX WITH ABASIC DNA
(DNA-apurinic or apyrimidinic site lyase)
referenceFreudenthal et al. 'Nucleic 48 7345 2020
sourceHomo sapiens
experimentX-ray (resolution=2.77, R-factor=0.224)
structural superfamilyDNase I-like;
sequence familyEndonuclease/Exonuclease/phosphatase fa;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRNNAMM

Estimated binding specificities ?

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# IC=3.101 IC/col=0.517 n_of_columns=6 specificity:   
A |  13  24   0  24   0  13
C |  54  24   0  24  96  16
G |  13  24   0  24   0  54
T |  16  24  96  24   0  13
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updated Tue Dec 17 07:46:55 2024