6w89_AD : 3D-footprint complex

structure name	STRUCTURE OF DNMT3A (R882H) IN COMPLEX WITH CGA DNA
reference	Anteneh et al. 'Nat 11 2294 2020
source	HOMO SAPIENS
experiment	X-ray (resolution=2.50, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6pa7_K
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6w89_A interface=88,89,91,204,207,209,210,211,219, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVnParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvRtiTtRSNsikqgkdQhfpvfmnekedilwctemervfgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv > 6w89_D interface=88,89,91,209,211,219, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVnParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtittRsNsikqgkdQhfpvfmnekedilwctemervfgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVPRTRSNQ/IVPRNQ

Estimated binding specificities ?

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# IC=11.096 IC/col=0.653 n_of_columns=17

specificity:

A |   0   0  96  11   0  24  24  24  24  24  24   0  69   0   6   1  62
C |   5   0   0  11  96  24  24  24  24  24  24   0  11   0  90  90  13
G |  90  96   0  16   0  24  24  24  24  24  24  96   5   0   0   0  16
T |   1   0   0  58   0  24  24  24  24  24  24   0  11  96   0   5   5

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updated Fri Jun 26 02:25:05 2026