6w89_AD : 3D-footprint complex

structure name	STRUCTURE OF DNMT3A (R882H) IN COMPLEX WITH CGA DNA
reference	Anteneh et al. 'Nat 11 2294 2020
source	HOMO SAPIENS
experiment	X-ray (resolution=2.50, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6w8b_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6w89_A interface=88,89,91,204,207,209,210,211,219, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVnParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvRtiTtRSNsikqgkdQhfpvfmnekedilwctemervfgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv > 6w89_D interface=88,89,91,209,211,219, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVnParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtittRsNsikqgkdQhfpvfmnekedilwctemervfgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVPRTRSNQ/IVPRNQ

Estimated binding specificities ?

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# IC=10.081 IC/col=0.630 n_of_columns=16

specificity:

A |   6   0  96   8   0  24  24  24  24  24  24   0  57   0   0   6
C |   2   0   0   6  96  24  24  24  24  24  24   0  12   0  96  76
G |  76  89   0   6   0  24  24  24  24  24  24  96   6   0   0  14
T |  12   7   0  76   0  24  24  24  24  24  24   0  21  96   0   0

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updated Tue Sep 10 22:50:24 2024