6w89_AD : 3D-footprint complex

structure name	STRUCTURE OF DNMT3A (R882H) IN COMPLEX WITH CGA DNA
reference	Anteneh et al. 'Nat 11 2294 2020
source	HOMO SAPIENS
experiment	X-ray (resolution=2.50, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6w8b_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6w89_A interface=88,89,91,204,207,209,210,211,219, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVnParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvRtiTtRSNsikqgkdQhfpvfmnekedilwctemervfgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv > 6w89_D interface=88,89,91,209,211,219, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVnParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtittRsNsikqgkdQhfpvfmnekedilwctemervfgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVPRTRSNQ/IVPRNQ

Estimated binding specificities ?

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# IC=10.988 IC/col=0.646 n_of_columns=17

specificity:

A |   5   0  96  11   0  24  24  24  24  24  24   0  75   0   0   0  60
C |   5   0   0  10  96  24  24  24  24  24  24   0   6   0  96  86  10
G |  80  96   0  15   0  24  24  24  24  24  24  96  10   0   0   0  15
T |   6   0   0  60   0  24  24  24  24  24  24   0   5  96   0  10  11

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updated Thu Jul 31 04:17:59 2025