6w8d_AD : 3D-footprint complex

structure name	STRUCTURE OF DNMT3A (R882H) IN COMPLEX WITH CGT DNA
reference	Anteneh et al. 'Nat 11 2294 2020
source	HOMO SAPIENS
experiment	X-ray (resolution=2.60, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6w8b_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6w8d_A interface=87,88,89,90,208,210, ekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtittRsNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv > 6w8d_D interface=88,89,91,209, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVnParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtittRsnsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVNPRN/IVPR

Estimated binding specificities ?

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# IC=7.952 IC/col=0.398 n_of_columns=20

specificity:

A |  15   0  24   0  16  24  24  24  24  24  24  24  24  24  57  61   0  24   0  92
C |  13   0  24   0  11  24  24  24  24  24  24  24  24  24  11  17  96  24  96   0
G |  11  96  24  96   0  24  24  24  24  24  24  24  24  24  15   7   0  24   0   0
T |  57   0  24   0  69  24  24  24  24  24  24  24  24  24  13  11   0  24   0   4

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updated Thu Jul 31 04:19:40 2025