6w8d_AD : 3D-footprint complex

structure name	STRUCTURE OF DNMT3A (R882H) IN COMPLEX WITH CGT DNA
reference	Anteneh et al. 'Nat 11 2294 2020
source	HOMO SAPIENS
experiment	X-ray (resolution=2.60, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6pa7_K
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6w8d_A interface=87,88,89,90,208,210, ekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVNParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtittRsNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv > 6w8d_D interface=88,89,91,209, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVnParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtittRsnsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVNPRN/IVPR

Estimated binding specificities ?

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# IC=7.834 IC/col=0.392 n_of_columns=20

specificity:

A |   0   0  24   0  12  14  24  24  24  24  24  24  24  24  24  59   0  24   0  64
C |   0   0  24   0  14  18  24  24  24  24  24  24  24  24  24  16  96  24  96   7
G |   0  96  24  96  11  13  24  24  24  24  24  24  24  24  24  14   0  24   0  14
T |  96   0  24   0  59  51  24  24  24  24  24  24  24  24  24   7   0  24   0  11

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updated Tue Jan 6 15:51:43 2026