6w8j_AD : 3D-footprint complex

structure name	STRUCTURE OF DNMT3A (R882H) IN COMPLEX WITH CAG DNA
reference	Anteneh et al. 'Nat 11 2294 2020
source	HOMO SAPIENS
experiment	X-ray (resolution=2.44, R-factor=?)
structural superfamily	S-adenosyl-L-methionine-dependent methyltransferases;
reference complex	6pa7_K
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6w8j_A interface=87,88,90,206,208,210, ekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVnParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtiTtRsNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmshlarqrllgrswsvpvirhlfaplkeyfacv > 6w8j_D interface=88,89,91,209,210,211,256, aekrkpirvlslfdgiatgllvlkdlgiqvdryiasevcedsitvgmvrhqgkimyvgdvrsvtqkhiqewgpfdlviggspcndlsIVnParkglyegtgrlffefyrllhdarpkegddrpffwlfenvvamgvsdkrdisrflesnpvmidakevsaahraryfwgnlpgmnrplastvndklelqeclehgriakfskvrtittRSNsikqgkdqhfpvfmnekedilwctemervfgfpvhytdvsnmshLarqrllgrswsvpvirhlfaplkeyfacv
interface signature	IVPTRN/IVPRSNL

Estimated binding specificities ?

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# IC=8.114 IC/col=0.477 n_of_columns=17

specificity:

A |  21   0  96   0  24  24  24  24  24  24  24  24  24  42   0   0   0
C |  21   0   0   0  24  24  24  24  24  24  24  24  24  12  96   0  96
G |  21  96   0  96  24  24  24  24  24  24  24  24  24  21   0   0   0
T |  33   0   0   0  24  24  24  24  24  24  24  24  24  21   0  96   0

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updated Fri Jun 26 02:27:12 2026