6wie_A : 3D-footprint complex

3D-footprint cannot reliably estimate the specificity of 'DNA polymerase beta, N-terminal domain-like', as these often contain single-stranded DNA molecules which accumulate many base contacts which distort the calculations.

Dendrogram of similar interfaces ?

matrix format

structure name	POST-CATALYTIC NICKED COMPLEX OF HUMAN POLYMERASE MU ON A COMPLEMENTARY DNA DOUBLE-STRAND BREAK SUBSTRATE (DNA-DIRECTED DNARNA POLYMERASE MU)
reference	Kaminski et al. 'Nat 11 4784 2020
source	HOMO SAPIENS
experiment	X-ray (resolution=1.50, R-factor=0.170)
structural superfamily	Nucleotidyltransferase;DNA polymerase beta, N-terminal domain-like;PsbU/PolX domain-like;
sequence family	Fingers domain of DNA polymerase lamb;
redundant complexes	5tyx 4m0a 5tyy 5tye 5tyz 5tyf 5tyg 6p1u 5vzi 5vz9 5vzf 5vzc 6p1s 5twq 5tws
reference complex	5vzi_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6wie_A interface=141,234,236,273,276,277,280, pawmpayacqrptplthhntglsealeilaeaagfegsegrlltfcraasvlkalpspvttlsqlqglphfgehssrvvqellehgvceevervrrseryqtmklftqifgvgvktadrwyreglrtlddlreqpqkltqQqkaglqhhqdlstpvlrsdvdalqqvveeavgqalpgatvtltggfrrgklqghdvdflithpkegqeagllprvmcrlqdqglilyhqhfeRsFcifrlpqpgswkavrvdlvvapvsqfpfallgwtgsKlfQRelRrfsrkekglwlnshglfdpeqktffqaaseedifrhlgleylppeqrna

  
  ------LC--RCRAFT--KTQTRART----                              +6wie_A    
                                                            +-2 
  ----SALTAART------RGEGRGRG----                            ! ! +4qz9_A    
                                              +-------------3 +-1 
  ----SALTAART------RGEGRGRG----              !             !   +6go6_A    
                                              !             ! 
  --HCKG--AG--KG--YG----KARA----              !             +--5wo0_A    
                                       +------6 
  --WC--LC----KA--YCAGNGRCRG--EG       !      !     +----------2bcq_A    
                                       !      ! +---4 
  ------------KC----KA--VARA----     --7      +-5   +----------4p4m_A    
                                       !        ! 
  ------------KT--HCVGLCIGRG----       !        +--------------5hrb_A    
                                       ! 
  NGFGRGRCAG--------KC--ICRCET--   L   +-----------------------3auo_B

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updated Mon Dec 18 18:57:32 2023