6x1j_A : 3D-footprint complex

structure name	THE HOMING ENDONUCLEASE I-WCAI BOUND TO ITS DNA RECOGNITION SEQUENCE (Probable intron-encoded endonuclease 1)
reference	Nawimanage et al. J.Mol.Biol. 434 167550 2022
source	Wickerhamomyces canadensis
experiment	X-ray (resolution=1.95, R-factor=0.229)
structural superfamily	Homing endonucleases;
sequence family	LAGLIDADG DNA endonuclease family;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6x1j_A interface=12,13,44,46,48,50,57,59,84,86,88,89,94,96,98,100,148,149,161,163,190,191, iinkkdllglgPNsklikdykkqwttlskiqeetlignilgdvYiKkLkRnkhfllQfEwknkayiehivrvfdeyvispptlYeRkNHlgnkViTwRaQtfehkafdklgyyfmenhkkiikpdlvlnyiterslaywfmddggkwDYnkktknkslvlHtQgfkkeeveilindlnikfnlncsikfNKnkpiiyipnkdyelfynlvnpyiipemkykllfnv
interface signature	PNYKLRQEYRNHVTRQDYHQNK

Estimated binding specificities ?

readout + contact

# IC=14.902 IC/col=0.828 n_of_columns=18

specificity:

A |   0  24   0   0   0  96  24  24  61   0  96   0   4  24   9  73  77   0
C |   5  24   1   0   0   0  24  24   4  96   0   0   0  24   9   9   6   4
G |   0  24  91  96  96   0  24  24  27   0   0  96  92  24   4  10   4   0
T |  91  24   4   0   0   0  24  24   4   0   0   0   0  24  74   4   9  92

scan!

Dendrogram of similar interfaces ?

matrix format

  
  PTNTYGRGRGQGEC------KTRGVAQC------DTYCNT----NCQC----NGKG--------   L       +-----------------------------1r7m_B    
                                                                           +-1 
  ------------RG--------------SA--FC--RG--QGEA----YT------WCQGRTEC   L   +-2 +-----------------------------7rcc_D    
                                                                         ! ! 
  ----------QT----------------SAKG------------------YC------RTEAVG   L --3 +-----------------------------4yis_A    
                                                                         ! 
  --------------NCKGRA--------------------------------------------   L   +-----------------------------2ayg_A

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updated Tue Jun 30 02:50:14 2026