6x1j_A : 3D-footprint complex

structure name	THE HOMING ENDONUCLEASE I-WCAI BOUND TO ITS DNA RECOGNITION SEQUENCE (Probable intron-encoded endonuclease 1)
reference	Nawimanage et al. J.Mol.Biol. 434 167550 2022
source	Wickerhamomyces canadensis
experiment	X-ray (resolution=1.95, R-factor=0.229)
structural superfamily	Homing endonucleases;
sequence family	LAGLIDADG DNA endonuclease family;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6x1j_A interface=12,13,44,46,48,50,57,59,84,86,88,89,94,96,98,100,148,149,161,163,190,191, iinkkdllglgPNsklikdykkqwttlskiqeetlignilgdvYiKkLkRnkhfllQfEwknkayiehivrvfdeyvispptlYeRkNHlgnkViTwRaQtfehkafdklgyyfmenhkkiikpdlvlnyiterslaywfmddggkwDYnkktknkslvlHtQgfkkeeveilindlnikfnlncsikfNKnkpiiyipnkdyelfynlvnpyiipemkykllfnv
interface signature	PNYKLRQEYRNHVTRQDYHQNK

Estimated binding specificities ?

readout + contact

# IC=14.865 IC/col=0.826 n_of_columns=18

specificity:

A |   1  24   2   0   0  96  24  24  59   0  96   0   4  24   4  79  73   0
C |   4  24   4   0   0   0  24  24   4  96   0   0   0  24   6   9  10   0
G |   0  24  86  96  96   0  24  24  22   0   0  96  92  24   9   4   4   0
T |  91  24   4   0   0   0  24  24  11   0   0   0   0  24  77   4   9  96

scan!

Dendrogram of similar interfaces ?

matrix format

  
  PTNTYGRGRGQGEC------KTRGVAQC------DTYCNTNCQC------NGKG--------   L     +-----------------------------1r7m_B    
                                                                       +-2 
  ----------------------------CA--FT----------YTLAKG----FTWC--TT   L   ! !                            +6uw0_B    
                                                                     --3 +----------------------------1 
  ----------QT----------------SAKG----------------YC------RTEAVG   L   !                              +4yis_A    
                                                                       ! 
  --------------NCKGRA------------------------------------------   L   +-----------------------------2ayg_A

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updated Sat Jan 10 13:05:22 2026