6zy5_AB : 3D-footprint complex

structure name	CRYO-EM STRUCTURE OF THE HUMAN TOPOISOMERASE II ALPHA DNA- BINDING/CLEAVAGE DOMAIN IN STATE 1
experiment	NMR
structural superfamily	Type II DNA topoisomerase;
reference complex	6zy5_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6zy5_A interface=57,330,331,334,424, nrikgipklddandaggrnstectliltegdsaktlavsglgvvgrdkygvfplrgKilnvreashkqimenaeinniikivglqykknyededslktlrygkimimtdqdqdgshikgllinfihhnwpsllrhrfleefitpivkvsknkqemafyslpefeewksstpnhkkwkvkyykglgtstskeakeyfadmkrhriqfkysgpeddaaislafskkqiddrkewltnfmedrrqrkllglpedylygqtttyltyndfinkelilfsnsdnersipsmvdglkpgqrkvlftcfkrndkrevkvaqlagsvaemssyhhgeMSlmMtiinlaqnfvgsnnlnllqpigqfgtrlhggkdsaspryiftmlsslarllfppkddhtlkflyddnqrvepewyipiipmvlingaegIgtgwsckipnfdvreivnnirrlmdgeeplpmlpsyknfkgtieelapnqyvisgevailnsttieiselpvrtwtqtykeqvlepmlngtektpplitdyreyhtdttvkfvvkmteeklaeaervglhkvfklqtsltcnsmvlfdhvgclkkydtvldilrdffelrlkyyglrkewllgmlgaesaklnnqarfilekidgkiiienkpkkelikvliqrgydsdpvkawkeaqqkvsgptfnylldmplwyltkekkdelcrlrnekeqeldtlkrkspsdlwkedlatfieeleaveakekqdeqvglpgkggkakgkktqmaevlpspr > 6zy5_B interface=57,330,331,334,422,424,429, nrikgipklddandaggrnstectliltegdsaktlavsglgvvgrdkygvfplrgKilnvreashkqimenaeinniikivglqykknyededslktlrygkimimtdqdqdgshikgllinfihhnwpsllrhrfleefitpivkvsknkqemafyslpefeewksstpnhkkwkvkyykglgtstskeakeyfadmkrhriqfkysgpeddaaislafskkqiddrkewltnfmedrrqrkllglpedylygqtttyltyndfinkelilfsnsdnersipsmvdglkpgqrkvlftcfkrndkrevkvaqlagsvaemssyhhgeMSlmMtiinlaqnfvgsnnlnllqpigqfgtrlhggkdsaspryiftmlsslarllfppkddhtlkflyddnqrvepewyipiipmvlingaEgIgtgwSckipnfdvreivnnirrlmdgeeplpmlpsyknfkgtieelapnqyvisgevailnsttieiselpvrtwtqtykeqvlepmlngtektpplitdyreyhtdttvkfvvkmteeklaeaervglhkvfklqtsltcnsmvlfdhvgclkkydtvldilrdffelrlkyyglrkewllgmlgaesaklnnqarfilekidgkiiienkpkkelikvliqrgydsdpvkawkeaqqkvsgptfnylldmplwyltkekkdelcrlrnekeqeldtlkrkspsdlwkedlatfieeleaveakekqdeqvglpgkggkakgkktqmaevlpspr
interface signature	KMSMI/KMSMEIS

Estimated binding specificities ?

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# IC=8.520 IC/col=0.655 n_of_columns=13

specificity:

A |   4  24   8   4   0  24  24   4   4  82  24   0   0
C |   6  24  13   6  96  24  24   4  82   4  24  96   0
G |  82  24   6  82   0  24  24  84   4   4  24   0  96
T |   4  24  69   4   0  24  24   4   6   6  24   0   0

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updated Sat Dec 16 23:30:20 2023