7aij_AB : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND L-METHIONINE TENOFOVIR
reference	Martinez et al. J.Med.Chem. 64 782 2021
source	HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 BH10
experiment	X-ray (resolution=2.95, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7aij_A interface=95,116,158,184,185,357,449, vpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdaYfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgsPaifqssmtkilepfkkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndicklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyaRmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltnttnqktelqaiylalqdsglevnivtnsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklvsa > 7aij_B interface= pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpAglkkkksvtvldvgdayfsvPldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifQssmtkilepfkkqnpdiviyqymddLYvgsdleigqhrtkieelrqhllrwglwmgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqKittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq
interface signature	IYPYMRR/APQLYK

Estimated binding specificities ?

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# IC=4.475 IC/col=0.280 n_of_columns=16

specificity:

A |   0   0  13  24  24  24  24  24  24  24  24  24  24  24  13  96
C |   0   0  54  24  24  24  24  24  24  24  24  24  24  24  13   0
G |  96  96  16  24  24  24  24  24  24  24  24  24  24  24  57   0
T |   0   0  13  24  24  24  24  24  24  24  24  24  24  24  13   0

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updated Tue Jan 6 20:08:31 2026