7c17_ACDFGH : 3D-footprint complex

3D-footprint cannot reliably estimate the specificity of 'Nucleic acid-binding proteins', as they bind to single-stranded DNA and thus accumulate more base contacts.

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updated Sun Dec 15 03:08:42 2024

structure name	THE CRYO-EM STRUCTURE OF E. COLI CUER TRANSCRIPTION ACTIVATION COMPLEX WITH FULLY DUPLEX PROMOTER DNA
source	ESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12)
experiment	NMR
structural superfamily	Insert subdomain of RNA polymerase alpha subunit;C-terminal domain of RNA polymerase alpha subunit;RBP11-like subunits of RNA polymerase;cAMP-binding domain-like;"Winged helix" DNA-binding domain;P-loop containing nucleoside triphosphate hydrolases;Putative DNA-binding domain;beta and beta-prime subunits of DNA dependent RNA-polymerase;Nucleic acid-binding proteins;Rho N-terminal domain-like;Probable bacterial effector-binding domain;Homeodomain-like;lambda repressor-like DNA-binding domains;CheY-like;C-terminal effector domain of the bipartite response regulators;
reference complex	3iyd_A 3iyd_H 5nss_G 6ldi_G 6vu3_A 6vz3_A 6xas_B 6xh7_H 6xl5_H 7c97_K 7vwz_G 7w5x_A 8igr_C 8jo2_H 8u3b_G 8upo_A 8y6u_I
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7c17_A interface= teflkprlvdieqvssthakvtleplergfghtlgnalrrillssmpgcavteveidgvlheystkegvqedileillnlkglavrvqgkdeviltlnksgigpvtaadithdgdveivkpqhvichltdenasismrikvqrgrgyvpastrihseederpigrllvdacyspveriaynveaarveqrtdldklviemetngtidpeeairraatilaeqleafvdlrdpillrpvddleltvrsanclkaeaihyigdlvqrtevellktpnlgkkslteikdvlasrglslgmrlenwp > 7c17_C interface=197,199,369,372,479,539,540, ysytekkrirkdfgkrpqvldvpyllsiqldsfqkfieqdpegqygleaafrsvfpiqsysgnselqyvsyrlgepvfdvqecqirgvtysaplrvklrlviyereapegtvkdikeqevymgeiplmtdngtfvingtervivsqlhrspgvffdsdkgkthssgkvlynariipyrgswldfefdpkdnlfvriDrRrklpatiilralnytteqildlffekvifeirdnklqmelvperlrgetasfdieangkvyvekgrritarhirqlekddvklievpveyiagkvvakdyidestgelicaanmelsldllaklsqsghkrietlftndldhgpyisetlrvdptndrlsalveiyrmmRpgEpptreaaeslfenlffsedrydlsavgrmkfnrsllreeiegsgilskddiidvmkklidirngkgevddidhlgnrrirsvgemaenqfrvglvrveravkerlsLgdldtlmpqdminakpisaavkeffgssqlsqfmdqnnplseithkrrisalgpggltrERagfevrdvhpthygrvcpietpegpniglinslsvyaqtneygfletpyrkvtdgvvtdeihylsaieegnyviaqansnldeeghfvedlvtcrskgesslfsrdqvdymdvstqqvvsvgaslipflehddanralmganmqrqavptlradkplvgtgmeravavdsgvtavakrggvvqyvdasrivikvnedemypgeagidiynltkytrsnqntcinqmpcvslgepvergdvladgpstdlgelalgqnmrvafmpwngynfedsilvservvqedrfttihiqelacvsrdtklgpeeitadipnvgeaalskldesgivyigaevtggdilvgkvtpkgetqltpeekllraifgekasdvkdsslrvpngvsgtvidvqvftrdgvekdkraleieemqlkqakkdlseelqileaglfsriravlvaggveaekldklprdrwlelgltdeekqnqleqlaeqydelkhefekkleakrrkitqgddlapgvlkivkvylavkrriqpgdkmagrhgnkgviskinpiedmpydengtpvdivlnplgvpsrmnigqilethlgmaakgigdkinamlkqqqevaklrefiqraydlgadvrqkvdlstfsdeevmrlaenlrkgmpiatpvfdgakeaeikellklgdlptsgqirlydgrtgeqferpvtvgymymlklnhlvddkmharstgsyslvtqqplggkaqfggqrfgemevwaleaygaaytlqemltvksddvngrtkmyknivdgnhqmepgmpesfnvllkeirslginiele > 7c17_D interface=196,298,774,775, fdaikialaspdmirswsfgevkkpetinyrtfkperdglfcarifgpvkdyeclcgkykrlkhrgvicekcgvevtqtkvrrermghielasptahiwflkslpsrigllldmplrdiervlyfesyvvieggmtnlerqqilteeqyldaleefgdefdakmgaeaiqallksmdleqeceqlreelnetnseTkrkkltkriklleafvqsgnkpewmiltvlpvlppdlrplvpldggrfatsdlndlyrrvinrnnrlkrlldlaapdiivrnekrmlqeavdalldngrrgRaitgsnkrplksladmikgkqgrfrqnllgkrvdysgrsvitvgpylrlhqcglpkkmalelfkpfiygklelrglattikaakkmvereeavvwdildevirehpvllnraptlhrlgiqafepvliegkaiqlhplvcaaynadfdgdqmavhvpltleaqlearalmmstnnilspangepiivpsqdvvlglyymtrdcvnakgegmvltgpkeaerlyrsglaslharvkvriteyekdangelvaktslkdttvgrailwmivpkglpysivnqalgkkaiskmlntcyrilglkptvifadqimytgfayaarsgasvgiddmvipekkheiiseaeaevaeiqeqfqsglvtagerynkvidiwaaandrvskammdnlqtetvinrdgqeekqvsfnsiymmadsgargsaaqirqlagmrglmakpdgsiietpitanfreglnvlqyfisthgarkgladtalkTAnsgyltrrlvdvaqdlvvteddcgthegimmtpvieggdvkeplrdrvlgrvtaedvlkpgtadilvprntllheqwcdlleensvdavkvrsvvscdtdfgvcahcygrdlarghiinkgeaigviaaqsigepgtqltssiqvknkgsiklsnvksvvnssgklvitsrntelklidefgrtkesykvpygavlakgdgeqvaggetvanwdphtmpvitevsgfvrftdmidgqtitrqtdeltglsslvvldsaertaggkdlrpalkivdaqgndvlipgtdmpaqyflpgkaivqledgvqissgdtlaripqglprvadlfearrpkepailaeisgivsfgketkgkrrlvitpvdgsdpyeemipkwrqlnvfegervergdvisdgpeaphdilrlrgvhavtryivnevqdvyrlqgvkindkhievivrqmlrkativnagssdflegeqveysrvkianreleangkvgatysrdllgitkaslatesfisaasfqettrvlteaavagkrdelrglkenvivgrlipagtgyayhqdrmrrr > 7c17_F interface=4,6,7,10,13,18,19,24,236,238,239,241,254,273,276,278,281,282,283,285,286,287,289,290,293,294,308,311,437,438,439,441,442, rttDpVRmyMreMgtveLLtregEidiakriedginqvqcsvaeypeaitylleqydrveaensidpelarekfaelraqyvvtrdtikakgrshataqeeilklsevfkqfrlvpkqfdylvnsmrvmmdrvrtqerlimklcveqckmpkknfitlftgnetsdtwfnaaiamnkpwseklhdvseevhralqklqqieeetgltieqvkdinrrmsigeakarrakkemveaNlRLvIsiakkytnrglqFldliqegniglmkavdkfEyrRgYkfSTYaTWWiRQaiTRsiadqartiripvHmiEtinklnrisrqmlqemgreptpeelaermlmpedkirkvlkiakepismetpigddedshlgdfiedttlelpldsatteslraathdvlagltareakvlrmrfgidmntdytleevgkqfdvtRERiRQieakalrklrhpsrsevlrsfld > 7c17_G interface=15,18,19,36, mnisdvakitgltsKaiRFyeekglvtppmrsengYrtytqqhlneltllrqarqvgfnleesgelvnlfndpqrhsadvkrrtlekvaeierhieelqsmrdqllalanacpgddsadcpiienls > 7c17_H interface=14,15,18,19,36, mnisdvakitgltSKaiRFyeekglvtppmrsengYrtytqqhlneltllrqarqvgfnleesgelvnlfndpqrhsadvkrrtlekvaeierhieelqsmrdqllalanacpgddsadcpiienlsg