7eu9_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE SELENOMETHIONINE(SEMET)-DERIVED CAS12I1 R- LOOP COMPLEX BEFORE TARGET DNA CLEAVAGE (CAS12I1 D647A MUTANT)
reference	OuYang et al. 'Nat 12 3476 2021
source	LACHNOSPIRACEAE BACTERIUM ND2006
experiment	X-ray (resolution=2.35, R-factor=0.230)
redundant complexes	7d2l_A 7d3j_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7eu9_A interface=162,164,165,168,228,230,292,475,476, nasetrkayttkmiprshdrmkllgnfmdylmdgtpiffelwnqfgggidrdiisgtankdkisddlllavnwfkvmpinskpqgvspsnlanlfqqysgsepdiqaqeyfasnfdtekhqwkdmrveyerllaelqlsrsdmhhdlklmykekciglslsTaHYitSvmfgtgaknnrqtkhqfyskviqlleestqinsveqlasiilkagdcdsyrklrircsrKgAtpsilkivqdyelgtnhddevnvpslianlkeklgrfeyecewkcmekikaflaskvgpyyLgsysamlenalspikgmttknckfvlkqidakndikyenepfgkivegffdspyfesdtnvkwvlhphhigesniktlwedlnaihskyeediaslsedkkekrikvyqgdvcqtintyceevgkeaktplvqllrylysrkddiavdkiidgitflskkhkvekqkinpviqkypsfnfgnNSkllgkiispkdklkhnlkcnrnqvdnyiwieikvlntktmrwekhhyalsstrfleevyypatsenppdalaarfrtktngyegkpalsaeqieqirsapvglrkvkkrqmrleaarqqnllprytwgkdfninickrgnnfevtlatkvkkkkeknykvvlgyaanivrkntyaaieahangdgvidyndlpvkpiesgfvtvesqvrdksydqlsyngvkllyckphvesrrsflekyrngtmkdnrgnniqidfmkdfeaiaddetslyyfnmkyckllqssirnhssqakeyreeifellrdgklsvlklsslsnlsfvmfkvaksligtyfghllkkpkappitdedkqkadpemfalrlaleekrlnkvkskkeviankivakalelrdkygpvlikgenisdttkkgkksstnsflmdwlargvankvkemvmmhqglefvevnpnftshqdpfvhknpentfrarysrctpselteknrkeilsflsdkpskrptnayynegamaflatyglkkndvlgvslekfkqimanilhqrsedqllfpsrggmfylatykldadatsvnwngkqfwvcnadlvaaynvglvdiqkdfk
interface signature	THYSKALNS

Estimated binding specificities ?

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# IC=2.857 IC/col=0.714 n_of_columns=4

specificity:

A |  23   0   0  18
C |  22   2   6  64
G |  42   1   0   3
T |   9  93  90  11

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RA--TGHTYCSTKTATLTKT----------NASAAA--ICDGYT--IGSG----KC--TGFGLC--WC----NGPGNA------KT   L              +-----------------7eu9_A    
                                                                                                 +--------1 
  TGSG------------------------DTSANA------------------------------MT--------------------   L   +-2        +-----------------5wti_Z    
                                                                                               ! ! 
  VGSG----------------QATARTRTST--NA----------KC--EGYGFCRGSTETQT--------------ACFGRCRT--   L --3 +--------------------------5u30_A    
                                                                                               ! 
  --------------------------------YA--SC------------------------------ATNT--------------   L   +---------------------------7c7l_A

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updated Tue Dec 19 18:16:32 2023