7lhz_AB : 3D-footprint complex

structure name	K. PNEUMONIAE TOPOISOMERASE IV (PARE-PARC) IN COMPLEX WITH DNA AND (3S)-10-[(3R)-3-(1-AMINOCYCLOPROPYL)PYRROLIDIN-1-YL]-9-FLUORO-3- METHYL-5-OXO-2,3-DIHYDRO-5H-[1,4]OXAZINO[2,3,4-IJ]QUINOLINE-6- CARBOXYLIC ACID (COMPOUND 25)
reference	Bellamacina et al. J.Med.Chem. 64 6329 2021
experiment	X-ray (resolution=3.30, R-factor=?)
structural superfamily	Type II DNA topoisomerase;
reference complex	6waa_D
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7lhz_A interface=44,252,302,303,304,395,549, kladctaqdlnrtelflvegdsaggsakqardreyqaimplkgKilntwevssdevlasqevhdisvaigidpdsddlsqlrygkiciladadsdglhiatllcalfvrhfrtlvkeghvyvalpplyridlgkevyyalteeektgvleqlkrkkgkpnvqrfkglgemnpmqlrettldpntrrlvqlvisdedeqqttaimdmllakkrsedrrnwlqekgdmaderlalheftenaylnysmyvimdRalpfigdglkpvqrrivyamselglnasakfkksartvgdvlgkyhphgDSAcyeamvlmaqpfsyryplvdgqgnwgapddpksfaamrytesrlskyaelllselgqgtvdwvpnfdgtlqepkmlparlpnillngttgIavgmatdipphnlrevakaaitlieqpkttldelldivqgpdfpteaeiitsraeirkiyqngrgsvrmravwskedgavvitalphqvsgakvleqiaaqmrnkklpmvddlrdesdhenptrlvivprsnrvdmeqvmnhlfattdleksyRinlnmigldgrpavknlleilsewlvfrrdtvrrrlnhrlekvlkrlhilegllvaflnidevieiirtedepkpalmsrfgisetqaeailelklrhlakleemkirgeqselekerdqlqailaserkmnnllkkelqadadafgddrrsplher > 7lhz_B interface=46,271,272,273,364, pgkladctaqdlnrtelflvegdsaggsakqardreyqaimplkgKilntwevssdevlasqevhdisvaigidpdsddlsqlrygkiciladadsdglhiatllcalfvrhfrtlvkeghvyvalpplyqrfkglgemnpmqlrettldpntrrlvqlvisdedeqqttaimdmllakkrsedrrnwlqekgsdmaerlalheftenaylnysmyvimdralpfigdglkpvqrrivyamselglnasakfkksartvgdvlgkyhphgDSAcyeamvlmaqpfsyryplvdgqgnwgapddpksfaamrytesrlskyaelllselgqgtvdwvpnfdgtlqepkmlparlpnillngttgIavgmatdipphnlrevakaaitlieqpkttldelldivqgpdfpteaeiitsraeirkiyqngrgsvrmravlphqvsgakvleqiaaqmrneqvmnhlfattdleksyrinlnmigldgrpavknlleilsewlvfrrdtvrrrlnhrlekvlkrlhilegllvaflnidevieiirtedepkpalmsrfgisetqaeailelklrhlakleemkirgeqselekerdqlqailaserkmnnllkkelqadadafgddrrsplher
interface signature	KRDSAIR/KDSAI

Estimated binding specificities ?

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# IC=9.464 IC/col=0.676 n_of_columns=14

specificity:

A |   0   0  24  60   6   0  24  24   0  50  15  24   0  96
C |   0   0  24  10   5   0  24  24  96  16  10  24  96   0
G |   0  96  24  16   5  96  24  24   0  15  15  24   0   0
T |  96   0  24  10  80   0  24  24   0  15  56  24   0   0

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updated Sun Dec 17 05:36:06 2023