7m7n_A : 3D-footprint complex

structure name	HUMAN DNA POL ETA WITH 2'-FA-ENDED PRIMER AND DAMPNPP (DNA polymerase eta)
reference	Gregory et al. Proc.Natl.Acad.Sci.USA 118 ? 2021
source	Homo sapiens
experiment	X-ray (resolution=1.31, R-factor=0.186)
structural superfamily	DNA/RNA polymerases;Lesion bypass DNA polymerase Y-family, little finger domain;
sequence family	impB/mucB/samB family;
redundant complexes	6mxo 6m7p 7m82 7u82 6m7t 7m83 7u83 6m7u 7m84 7u84 6m7v 7m85 4j9s 7m86 4j9o 7m87 7m88 7m89 7m8a 7m8b 6pl7 7m8c 6pl8 7m8d 6mp3 4ed1 4j9n 4dl6 4ed7 5ewe 5ewf 4ecv 5ewg 4rno 4ecs 4j9k 4j9l 6wk6 6uqi 4ru9 7lcd 5kfa 4dl7 5kfb 5f9l 5kfc 5f9n 5kfd 5kfe 6mq8 5kff 5kfg 5kfh 4yp3 5kfi 4ecu 5kfj 4dl2 4j9q 5kfk 4ed2 5kfl 4ecq 5kfm 4yqw 5dg9 5kfn 4ecw 5jum 4yr0 5dlf 5kfo 4yr2 5l9x 5dlg 5kfp 4ed3 4yr3 5dqg 5kfq 5dqh 3mr2 5kfr 5dqi 3mr3 5kfs 3mr5 5kft 3mr6 5kfu 3tq1 5kfv 7u72 6w5x 5kfw 4ecx 7u73 4o3n 5kfx 5l1i 6pz3 7u74 3si8 4o3o 5kfy 4ecz 5l1j 6q02 7u75 4dl3 4o3p 5kfz 4ed6 5l1k 7u76 4o3q 5kg0 4q8e 5l1l 7u77 4o3r 5kg1 7u78 4o3s 5kg2 4q8f 7u79 5kg3 4ed0 7u7a 5kg4 4j9r 7u7b 4rnm 5kg5 7u7c 4rnn 5kg6 4j9p 7u7d 5kg7 6plc 7u7e 7u7f 7u7g 4eey 3jaa 5dg7 7u7i 7m7l 5dg8 6ui2 7u7j 7m7m 5dga 6d0m 7u7k 5dgb 6d0z 7u7l 4ecy 7m7o 7u7r 7l69 7m7p 4j9m 7u7s 7m7q 7u7t 7m7r 7u7u 4dl4 4ect 7m7s 7u7v 4ed8 4dl5 7m7t 7u7w 7m7u 7u7x 7m7y 7u7y 4ecr 7m7z 7u7z 6v5k 7m80 7u80 6m7o 7m81 7u81
reference complex	3jaa_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7m7n_A interface=317,377, gphmatgqdrvvalvdmdcffvqveqrqnphlrnkpcavvqykswkgggiiavsyearafgvtrsmwaddakklcpdlllaqvresrgkanltkyreasvevmeimsrfavierasideayvdltsavqerlqklqgqpisadllpstyieglpqgqkegmrkqglfqwldslqidnltspdlqltvgaviveemraaieretgfqcsagishnkvlaklacglnkpnrqtlvshgsvpqlfsqmpirkirslggklgasvieilgieymgeltqftesqlqshfgekngswlyamcrgiehdpvkprqlpktigcSknfpgktalatreqvqwwllqlaqeleerltkdrndndrvatqlvvsirvqgdkrlsslRrccaltrydahkmshdaftvikncntsgtewsppltmlflcatkfsas

No structural evidence for specific binding to DNA (<4 informative columns)

Dendrogram of similar interfaces ?

matrix format

  
  ----QTWA----IT--------------------------ST--PATA------------------RC------                             +-----7m7n_A    
                                                                                                     +---6 
  --------------------------------------MANG----------YA--RC--ST------------                         !   +-----3mfi_A    
                                                                                                  +--7 
  ----------VASA----AAPT--MT----------------EG----RT--------FT--------RT----                      !  !         +5yuy_A    
                                                                                                  !  !       +-3 
  ----------MASA----AAPC--IC--------------EG--------------------TG--------RG                      !  +-------4 +2oh2_B    
                                                                                                  !          ! 
  ----------MA--------PAFAIA--------------EC------------FT------TG----------         +------------8          +-7nv0_A    
                                                                                     !            ! 
  ----VG----AGAG------PC--------------------IC------HA------------ST----RGRG         !            !            +4f4w_A    
                                                                                     !            !        +---2 
  FCYC----------TTAT--------SCICDCEC--ST--------------------------SG----RCRT       +-9            +--------5   +4tqr_A    
                                                                                   ! !                     ! 
  ----HT--ST----------WG----------------------------------------------------       ! !                     +---6x6z_A    
                                                                                   ! ! 
  ----------------------------------RT--------------------------------------     -10 !                         +3n4m_B    
                                                                                   ! +-------------------------1 
  ----------------------------------RA--------------------------------------       !                           +6b6h_I    
                                                                                   !  
  ----------------------------------RG--------------------------------------       +--------------------------5tw1_T

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updated Mon Dec 18 20:56:37 2023