7mkj_IJLR : 3D-footprint complex

structure name	CRYO-EM STRUCTURE OF ESCHERICHIA COLI RNA POLYMERASE BOUND TO T7A1 PROMOTER DNA
source	ESCHERICHIA COLI
experiment	NMR
structural superfamily	Insert subdomain of RNA polymerase alpha subunit;C-terminal domain of RNA polymerase alpha subunit;RBP11-like subunits of RNA polymerase;
reference complex	3iyd_A 6psq_M 7c97_K 8y6u_I
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7mkj_I interface=150,174,181,182,198,366,370,373,393,469,472,477,496,502,503,507,537,541, vysytekkrirkdfgkrpqvldvpyllsiqldsfqkfieqdpegqygleaafrsvfpiqsysgnselqyvsyrlgepvfdvqecqirgvtysaplrvklrlviyereapegtvkdikeqevymgeiplmtdngtfvingtervivsqlhRspgvffdsdkgkthssgkvlynaRiipyrgSWldfefdpkdnlfvriDrrrklpatiilralnytteqildlffekvifeirdnklqmelvperlrgetasfdieangkvyvekgrritarhirqlekddvklievpveyiagkvvakdyidestgelicaanmelsldllaklsqsghkrietlftndldhgpyisetlrvdptndrlsalveiYrmmRpgEpptreaaeslfenlffsedRydlsavgrmkfnrsllreeiegsgilskddiidvmkklidirngkgevddidhlgnrrirsvgemaenqfrvglvRveRavkeRlslgdldtlmpqdminakPisaavKEffgSsqlsqfmdqnnplseithkrrisalgpggLtreRagfevrdvhpthygrvcpietpegpniglinslsvyaqtneygfletpyrkvtdgvvtdeihylsaieegnyviaqansnldeeghfvedlvtcrskgesslfsrdqvdymdvstqqvvsvgaslipflehddanralmganmqrqavptlradkplvgtgmeravavdsgvtavakrggvvqyvdasrivikvnedemypgeagidiynltkytrsnqntcinqmpcvslgepvergdvladgpstdlgelalgqnmrvafmpwngynfedsilvservvqedrfttihiqelacvsrdtklgpeeitadipnvgeaalskldesgivyigaevtggdilvgkvtpkgetqltpeekllraifgekasdvkdsslrvpngvsgtvidvqvftrdgvekdkraleieemqlkqakkdlseelqileaglfsriravlvaggveaekldklprdrwlelgltdeekqnqleqlaeqydelkhefekkleakrrkitqgddlapgvlkivkvylavkrriqpgdkmagrhgnkgviskinpiedmpydengtpvdivlnplgvpsrmnigqilethlgmaakgigdkinamlkqqqevaklrefiqraydlgadvrqkvdlstfsdeevmrlaenlrkgmpiatpvfdgakeaeikellklgdlptsgqirlydgrtgeqferpvtvgymymlklnhlvddkmharstgsyslvtqqplggkaqfggqrfgemevwaleaygaaytlqemltvksddvngrtkmyknivdgnhqmepgmpesfnvllkeirslginieled > 7mkj_J interface=244, efdaikialaspdmirswsfgevkkpetinyrtfkperdglfcarifgpvkdyeclcgkykrlkhrgvicekcgvevtqtkvrrermghielasptahiwflkslpsrigllldmplrdiervlyfesyvvieggmtnlerqqilteeqyldaleefgdefdakmgaeaiqallksmdleqeceqlreelnetnsetkrkkltkriklleafvqsgnkpewmiltvlpvlppdlrplvpldggRfatsdlndlyrrvinrnnrlkrlldlaapdiivrnekrmlqeavdalldngrrgraitgsnkrplksladmikgkqgrfrqnllgkrvdysgrsvitvgpylrlhqcglpkkmalelfkpfiygklelrglattikaakkmvereeavvwdildevirehpvllnraptlhrlgiqafepvliegkaiqlhplvcaaynadfdgdqmavhvpltleaqlearalmmstnnilspangepiivpsqdvvlglyymtrdcvnakgegmvltgpkeaerlyrsglaslharvkvriteyekdangelvaktslkdttvgrailwmivpkglpysivnqalgkkaiskmlntcyrilglkptvifadqimytgfayaarsgasvgiddmvipekkheiiseaeaevaeiqeqfqsglvtagerynkvidiwaaandrvskammdnlqtetvinrdgqeekqvsfnsiymmadsgargsaaqirqlagmrglmakpdgsiietpitanfreglnvlqyfisthgarkgladtalktansgyltrrlvdvaqdlvvteddcgthegimmtpvieggdvkeplrdrvlgrvtaedvlkpgtadilvprntllheqwcdlleensvdavkvrsvvscdtdfgvcahcygrdlarghiinkgeaigviaaqsigepgtqltssiqvknkgsiklsnvksvvnssgklvitsrntelklidefgrtkesykvpygavlakgdgeqvaggetvanwdphtmpvitevsgfvrftdmidgqtitrqtdeltglsslvvldsaertaggkdlrpalkivdaqgndvlipgtdmpaqyflpgkaivqledgvqissgdtlaripqtgglprvadlfearrpkepailaeisgivsfgketkgkrrlvitpvdgsdpyeemipkwrqlnvfegervergdvisdgpeaphdilrlrgvhavtryivnevqdvyrlqgvkindkhievivrqmlrkativnagssdflegeqveysrvkianreleangkvgatysrdllgitkaslatesfisaasfqettrvlteaavagkrdelrglkenvivgrlipagtgyayhqdrmrrraa > 7mkj_L interface=9,10,13,16,21,27,243,245,246,253,254,256,257,261,279,280,283,285,288,289,290,292,293,296,297,300,315,318,325,328,365,444,445,446, eigrttdpVRmyMreMgtveLltregEidiakriedginqvqcsvaeypeaitylleqydrveaeearlsdlitgfvdpelarekfaelraqyvvtrdtikhataqeeilklsevfkqfrlvpkqfdylvnsmrvmmdrvrtqerlimklcveqckmpkknfitlftgnetsdtwfnaaiamnkpwseklhdvseevhralqklqqieeetgltieqvkdinrrmsigeakarrakkemveaNlRLvisiakKYtNRglqFldliqegniglmkavdkFEyrRgYkfSTYaTWwiRQaiTrsiadqartiripvHmiEtinklnRisRqmlqemgreptpeelaermlmpedkirkvlkiakepIsmetpigddedshlgdfiedttlelpldsatteslraathdvlagltareakvlrmrfgidmntdytleevgkqfdvtRERirqieakalrklrhpsrsevlrsfl > 7mkj_R interface= dpillrpvDDleLtvRsancLkaeaiHyigdlvqrtevellktpnlgkkslteikdvlasrglslgmrlenwp
interface signature	RRSWDYRERRRRPKESLR/R/VRMMLENRLKYNRFFERYSTYTWRQTHERRIRER/DDLRLH

Estimated binding specificities ?

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# IC=28.433 IC/col=0.693 n_of_columns=41

specificity:

A |   5  96   6   5   0  96   0  12  24  24  24  24  24  24  24  24  24  24  24  24   0  24  24  71   0   0  96   0  96   0   0   0  96   0  24  24  24   0  96   0   0
C |   5   0   5   5   0   0  96  10  24  24  24  24  24  24  24  24  24  24  24  24   0  24  24  10   0   0   0   0   0  96   0   0   0  96  24  24  24  96   0   0  96
G |   6   0   5   6  96   0   0  10  24  24  24  24  24  24  24  24  24  24  24  24   0  24  24  10  96  96   0   0   0   0   0   0   0   0  24  24  24   0   0   0   0
T |  80   0  80  80   0   0   0  64  24  24  24  24  24  24  24  24  24  24  24  24  96  24  24   5   0   0   0  96   0   0  96  96   0   0  24  24  24   0   0  96   0

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updated Thu Jul 31 15:02:15 2025