7ot6_AB : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-282
reference	Martinez et al. Eur.J.Med.Chem. 225 113785 2021
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7ot6_A interface=96,185,186,358,450, mvpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndicklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyaRmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltnttnqktelqaiylalqdsglevnivtnsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklvsa > 7ot6_B interface= pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaGlkkkksvtvldvgdayfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymddlYVgsdleigqhrtkieelrqhllrwglttpgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqKittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq
interface signature	IYMRR/GYVK

Estimated binding specificities ?

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# IC=4.064 IC/col=0.226 n_of_columns=18

specificity:

A |  86   0  24  24  24  24  24  24  24  24  24  24  24  24  24  12   0  10
C |   0   0  24  24  24  24  24  24  24  24  24  24  24  24  24  10  85  64
G |   0  96  24  24  24  24  24  24  24  24  24  24  24  24  24  64  10  10
T |  10   0  24  24  24  24  24  24  24  24  24  24  24  24  24  10   1  12

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updated Wed Jan 7 07:22:57 2026