7ot6_CD : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-282
reference	Martinez et al. Eur.J.Med.Chem. 225 113785 2021
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7ot6_C interface=95,116,184,185,357,449, vpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdaYfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndicklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyaRmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltnttnqktelqaiylalqdsglevnivtnsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklvsa > 7ot6_D interface= pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpAglkkkksvtvldvgdayfsvPldedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymddLYvgsdleigqhrtkieelrqhllrwglwmgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqKittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq
interface signature	IYYMRR/APLYK

Estimated binding specificities ?

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# IC=4.475 IC/col=0.280 n_of_columns=16

specificity:

A |   0  13  24  24  24  24  24  24  24  24  24  24  24  13   0   0
C |   0  54  24  24  24  24  24  24  24  24  24  24  24  13  96  96
G |   0  16  24  24  24  24  24  24  24  24  24  24  24  57   0   0
T |  96  13  24  24  24  24  24  24  24  24  24  24  24  13   0   0

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updated Wed Jan 7 07:22:19 2026