7otn_AB : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE COMPLEX WITH DNA AND INHIBITOR RMC-247
reference	Martinez et al. Eur.J.Med.Chem. 225 113785 2021
experiment	X-ray (resolution=3.40, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7otn_A interface=96,117,159,185,186,358,450,477, mvpispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgIphpaglkkkksvtvldvgdaYfsvpldedfrkytaftipsinnetpgiryqynvlpqgwkgsPaifqssmtkilepfkkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndicklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyaRmrgahtndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyqlekepivgaetfyvdgaanRetklgkagyvtnkgrqkvvpltnttnQktelqaiylalqdsglevnivtnsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahkgiggneqvdklvsa > 7otn_B interface= pietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaGlkkkksvtvldvgdayfsvpLdedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqSsmtkilepfkkqnpdiviyqymddlYVgsdleigqhrtkieelrqhllrwglttpgyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqKittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwyq
interface signature	IYPYMRRQ/GLSYVK

Estimated binding specificities ?

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# IC=4.514 IC/col=0.251 n_of_columns=18

specificity:

A |  48   0  20  24  24  24  24  24  24  24  24  24  24  24  24  13   0   0
C |  20   0  15  24  24  24  24  24  24  24  24  24  24  24  24  13  96  96
G |  13  96  13  24  24  24  24  24  24  24  24  24  24  24  24  54   0   0
T |  15   0  48  24  24  24  24  24  24  24  24  24  24  24  24  16   0   0

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updated Wed Jan 7 07:27:12 2026