7prv_AB : 3D-footprint complex

structure name	THE GLUCOCORTICOID RECEPTOR IN COMPLEX WITH FLUTICASONE FUROATE, A PGC1A COACTIVATOR FRAGMENT AND SGK 23BP
reference	Wissler et al. Nat.Struct.Mol.Biol. 30 286 2023
source	Homo sapiens
experiment	X-ray (resolution=2.70, R-factor=?)
structural superfamily	Nuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
reference complex	7prw_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7prv_A interface=26,27,31, ppklclvcsdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlltptlvslleviepevlyagydssvpdstwrimttlnmlggrqmiaavkwakaipgfrnlhlddqmtllqyswmslmafalgwrsyrqssanllcfapdliineqrmtlpdmydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngnikkllfhq > 7prv_B interface=15,25,26,30, pklclvcsdeasgcHygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqmiaavkwakaipgfrnlhlddqmtllqyswmslmafalgwrsyrqssanllcfapdliineqrmtlpdmydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngnikkllfhq
interface signature	KVR/HKVR

Estimated binding specificities ?

readout + contact

# IC=3.304 IC/col=0.300 n_of_columns=11

specificity:

A |  18  24  65   4  59  24  22  24  12   2  10
C |  26  24  11  82  12  23  23  24  14   2   9
G |  39  24  11   5  12  23  23  22  14  90  10
T |  13  24   9   5  13  26  28  26  56   2  67

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updated Sun Dec 17 10:52:05 2023