7prv_AB : 3D-footprint complex

structure name	THE GLUCOCORTICOID RECEPTOR IN COMPLEX WITH FLUTICASONE FUROATE, A PGC1A COACTIVATOR FRAGMENT AND SGK 23BP
reference	Wissler et al. Nat.Struct.Mol.Biol. 30 286 2023
source	Homo sapiens
experiment	X-ray (resolution=2.70, R-factor=?)
structural superfamily	Nuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
reference complex	7prw_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7prv_A interface=26,27,31, ppklclvcsdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlltptlvslleviepevlyagydssvpdstwrimttlnmlggrqmiaavkwakaipgfrnlhlddqmtllqyswmslmafalgwrsyrqssanllcfapdliineqrmtlpdmydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngnikkllfhq > 7prv_B interface=15,25,26,30, pklclvcsdeasgcHygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqmiaavkwakaipgfrnlhlddqmtllqyswmslmafalgwrsyrqssanllcfapdliineqrmtlpdmydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngnikkllfhq
interface signature	KVR/HKVR

Estimated binding specificities ?

readout + contact

# IC=3.290 IC/col=0.299 n_of_columns=11

specificity:

A |  66   2  58  26  26  24  14   4  10  25  13
C |  10  88  13  23  24  25  12   4  10  24  38
G |  11   3  11  22  22  23  12  84  10  23  23
T |   9   3  14  25  24  24  58   4  66  24  22

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updated Wed Sep 11 12:21:21 2024