7prw_AB : 3D-footprint complex

structure name	THE GLUCOCORTICOID RECEPTOR IN COMPLEX WITH VELSECORAT, A PGC1A COACTIVATOR FRAGMENT AND SGK 23BP
reference	Wissler et al. Nat.Struct.Mol.Biol. 30 286 2023
source	Homo sapiens
experiment	X-ray (resolution=2.50, R-factor=?)
structural superfamily	Nuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
reference complex	7prw_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7prw_A interface=28,29,33, gpppklclvcsdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqmiaavkwakaipgfrnlhlddqmtllqyswmslmafalgwrsyrqssanllcfapdliineqrmtlpdmydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngnikkllfhqk > 7prw_B interface=25,26,30, pklclvcsdeasgchygvltcgscKVffkRavegqhnylcagrndciidkirrkncpacryrkclqagmnlpqltptlvslleviepevlyagydssvpdstwrimttlnmlggrqmiaavkwakaipgfrnlhlddqmtllqyswmslmafalgwrsyrqssanllcfapdliineqrmtlpdmydqckhmlyvsselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkregnssqnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngnikkllfhqk
interface signature	KVR/KVR

Estimated binding specificities ?

readout + contact

# IC=6.338 IC/col=0.576 n_of_columns=11

specificity:

A |  73   0  75  24  24  24   7   0   0  24   7
C |   7  96   7  24  24  24   7   0   0  24  73
G |   9   0   7  24  24  24   7  96   0  24   7
T |   7   0   7  24  24  24  75   0  96  24   9

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updated Sun Dec 15 12:59:22 2024