7r3x_A : 3D-footprint complex

structure name	THE CRYSTAL STRUCTURE OF THE L439V VARIANT OF POL2CORE IN COMPLEX WITH DNA AND AN INCOMING NUCLEOTIDE (DNA polymerase epsilon catalytic subunit A)
reference	Shcherbakova et al. 'Nucleic 50 8023 2022
source	Saccharomyces cerevisiae
experiment	X-ray (resolution=2.46, R-factor=0.212)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
sequence family	DNA polymerase family B, exonuclease do; DNA polymerase family B 933;
reference complex	4m8o_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7r3x_A interface=905,926, kyntlsnnyalsaqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsqenqgisgvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiirkedltmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynvkvdakhliedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettkpplkfpdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnendevallqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykssycshmdcfrwvkrdsylpqgsqgvkavtqsklgynpieldpelmtpyafekpqhlseysvsdavatyylymkyvhpfifslctiiplnpdetlrkgtgtlcemllmvqayqhnillpnkhtdpierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfsvevenkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasmypnimttnrlqpdsiktcarklkwawrgeffpskmdeynmikralqnetfpnknkfskkkvltfdelsyadqvihikkrlteysrkvyhrvkvseivereaivcqrenpfyvdtvksfrdrryefkglaktwkgnlskidpsdkhardeakkmivlydslqlahkvilnsfygyvmrkgsrwysmemagitcltgatiiqmaralvervgrpleldtdgiwcilpksfpetyfftlengkklylsypcsmlnyrvhqkftnhqyqelkdplnyiyethsentiffevdgpykamilpsskeegkgikKryavfnedgslaelkgfelkRrgelqliknfqsdifkvflegdtlegcysavasvcnrwldvldshglmlededlvslicenrsmsktlkeyegqkstsittarrlgdflgedmvkdkglqckyiisskpfnapvteraipvaifsadipikrsflrrwtldpsledldirtiidwgyyrerlgsaiqkiitipaalqgvsnpvprvehpdwlkrki
interface signature	KR

Estimated binding specificities ?

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# IC=2.250 IC/col=0.562 n_of_columns=4

specificity:

A |   7   9   7   7
C |  73   7   7   9
G |   9  73   9   7
T |   7   7  73  73

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updated Sat Aug 2 20:09:57 2025