7s81_IN : 3D-footprint complex

structure name	STRUCTURE OF HUMAN PARP1 DOMAINS (ZN1, ZN3, WGR, HD) BOUND TO A DNA DOUBLE STRAND BREAK.
reference	Rouleau-Turcotte et al. Mol.Cell 82 2939 2022
source	HOMO SAPIENS
experiment	X-ray (resolution=3.60, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;WGR domain-like;Domain of polyADP-ribose polymerase;
reference complex	3od8_G 4dqy_B 7s81_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7s81_I interface=14,40,44,45, sdklyrveyaksgRasckkcsesipkdslrmaimvqspmFdgkVPhwyhfscfwkvghsirhpdvevdgfselrwddqqkvkktaea > 7s81_N interface=13,39,43,44, dklyrveyaksgRasckkcsesipkdslrmaimvqspmFdgkVPhwyhfscfwkvghsirhpdvevdgfselrwddqqkvkktaeaggv
interface signature	RFVP/RFVP

Estimated binding specificities ?

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# IC=4.915 IC/col=0.410 n_of_columns=12

specificity:

A |  96  24   9   9  24  24  24  24   9   7  24   0
C |   0  24   7  73  24  24  24  24   7  73  24   0
G |   0  24  73   7  24  24  24  24  73   7  24   0
T |   0  24   7   7  24  24  24  24   7   9  24  96

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updated Thu Jul 31 20:16:19 2025