interface graph thumbnail
legend  pdf

structure nameHUMAN DNA POLYMERASE ETA-DNA-DGMPNPP TERNARY MISMATCH COMPLEX IN 1.0 MM MG2+ FOR 600S
(DNA polymerase eta)
referenceChang et al. 'Nat 13 2346 2022
sourceHomo sapiens
experimentX-ray (resolution=1.66, R-factor=0.185)
structural superfamilyDNA/RNA polymerases;Lesion bypass DNA polymerase Y-family, little finger domain;
sequence familyimpB/mucB/samB family;
reference complex3jaa_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRSLRF

Estimated binding specificities ?

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# IC=3.142 IC/col=0.524 n_of_columns=6 specificity:   
A |   0  13  24  24  54   0
C |  96  13  24  24  13   0
G |   0  57  24  24  13   0
T |   0  13  24  24  16  96
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updated Sat Aug 2 20:55:00 2025