7w1m_ABDEH : 3D-footprint complex

Interface of input file ?

structure name	CRYO-EM STRUCTURE OF HUMAN COHESIN-CTCF-DNA COMPLEX
experiment	NMR
structural superfamily	P-loop containing nucleoside triphosphate hydrolases;Smc hinge domain;ARM repeat;"Winged helix" DNA-binding domain;beta-beta-alpha zinc fingers;
reference complex	6wg3_A 6wg3_B 6wg3_D 6wg3_E 7w1m_C 7w1m_H
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7w1m_A interface= gflklieienfksykgrqiigpfqrftaiigpngsgksnlmdaisfvlgektsnlrvktlrdlihgapvgkpaanrafvsmvyseegaedrtfarvivggsseykinnkvvqlheyseeleklgilikarnflvfqgavesiamknpkertalfeeisrsgelaqeydkrkkemvkaeedtqfnyhrkkniaaerkeakqameklesvrdkfqetsdefeaarkrakkakqafeqikkerfdrfnacfesvatnideiykalsrnssaqaflgpenpeepyldginyncvapgkrfrpmdnlsggektvaalallfaihsykpapffvldeidaaldntnigkvanyikeqstcnfqaivislkeefytkaesligvypeqgdcviskvltfdltkypd > 7w1m_B interface= myikqviiqgfrsyrdqtivdpfsskhnvivgrngsgksnffyaiqfvlsdefshlrpeqrlallhegtgprvisafveiifdnsdnrlpidkeevslrrvigakkdqyfldkkmvtkndvmnllesagfsrsnpyyivkqgkinqmatapdsqrlkllrevagtrvyderkeesislmketegkrekinellkyieerlhtleeekeelaqyqkwdkmrraleytiynqelnetrakldelsakretsgeksrqlinhdtkelekmtnrqgmllkkkeecmkkirelgslpqeafekyqtlslkqlfrkleqcntelkkyshvnkkaldqfvnfseqkeklikrqeeldrgyksimelmnvlelrkyeaiqltfkqvsknfsevfqklvpggkatlvmkkgqftgvgirvsftgkqgemremqqlsggqkslvalalifaiqkcdpapfylfdeidqaldaqhrkavsdmimelavhaqfitttfrpellesadkfygvkfrnkvshidvitaemakdfveddtthg > 7w1m_D interface= tlfevvklgksamqsvvddwiesykqdrdialldlinffiqcsgcrgtvriemfrnmqnaeiirkmteefdedsgdypltmpgpqwkkfrsnfcefigvlirqcqysiiydeymmdtvislltglsdsqvrafrhtstlaamklmtalvnvalnlsihqdntqrqyeaernkmigkranerlelllqkrkelqenqdeienmmnsifkgifvhryrdaiaeiraicieeigvwmkmysdaflndsylkyvgwtlhdrqgevrlkclkalqslytnrelfpklelftnrfkdrivsmtldkeydvaveairlvtlilhgseealsnedcenvyhlvysahrpvavaageflhkklfsrhdpqaeealakrrgrnspngnlirmlvlffleselhehaaylvdslwessqellkdwecmtellleepvqgeeamsdrqesalielmvctirqaaeahppvgrgtgkrvltakerktqiddrnkltehfiitlpmllskysadaekvanllqipqyfdleiystgrmekhldallkqikfvvekhvesdvleacsktysilcseeytiqnrvdiarsqlidefvdrfnhsvedllqegeeaddddiynvlstlkrltsfhnahdltkwdlfgncyrllktgiehgampeqivvqalqcshysilwqlvkitdgspskedllvlrktvksflavcqqclsnvntpvkeqafmllcdllmifshqlmtggreglqplvfnpdtglqsellsfvmdhvfidqdeenqsmegdeedeankiealhkrrnllaafskliiydivdmhaaadifkhymkyyndygdiiketlsktrqidkiqcaktlilslqqlfnelvqeqgpnldrtsahvsgikelarrfaltfgldqiktreavatlhkdgiefafkyqnqkgqeypppnlaflevlsefsskllrqdkktvhsylekflteqmmerredvwlplisyrnsl > 7w1m_E interface= mmdsstfkrftasienildnledmlllgkhqlnelgsesakikamgimdklstdktvkvlnilekniqdgsklserlwrdlimervtksadaclttinimtspnmpkavyiedvierviqytkfhlqntlypqydpvyrqrvivmlynkvcdivsslselleiqlltdttilqvssmgitpffvenvselqlcaiklvtavfsryekhrqlileeiftslarlptskrslrnfrlpmyiqmvtalvlqliqcvvhlpdvvitnsyetamrtaqnflsiflkkcgskqgeedyrplfenfvqdllstvnkpewpaaelllsllgrllvhqfsnkstemalrvasldylgtvaarlrkdavtskmdeiqqlqkalldyldentetdpslvfsrkfyiaqwfrdttletekkeiettgqimhraenrkkflrsdtvdyddaclivrylasmrpfaqsfdiyltqilrvlgenaiavrtkamkclsevvavdpsilarldmqrgvhgrlmdnstsvreaavellgrfvlcrpqlaeqyydmlierildtgisvrkrvikilrdicieqptfpkitemcvkmirrvndeegikklvnetfqklwftptphndkeamtrkilnitdvvaacrdtgydwfeqllqnllkseedssykpvkkactqlvdnlvehilkyeensgrlvacittlflfskirpqlmvkhamtmqpylttkcstqndfmvicnvakilelvvplmehpsetflatieedlmkliikygmtvvqhcvsclgavvnkvtqnfkfvwacfnryygaisklksqhqedpnntslltnkpallrslftvgalcrhfdfdledfkgnskvnikdkvlellmyftkhsdeevqtkaiiglgfafiqhpslmfeqevknlynnilsdknssvnlkiqvlknlqtylqeedtrmqqadrdwkkvakqedlkemgdvssgmsssimqlylkqvleaffhtqssvrhfalnvialtlnqglihpvqcvpyliamgtdpepamrnkadqqlveidkkyagfihmkavagmkmsyqvqqainsalcshlysmirgnrqhrraflisllnlfddtaktdvtmllyiadnlacfpyqtqeeplfimhhiditlsvsgsnllqsfkesliefanvsqgillllmlkqhlknlcgfsdskiqkyspsesakvydkainrktgvhfhpkqtldflrsdmanskiteevkrsivkqyldfkllmehl > 7w1m_H interface=22,24,28,49,53,78,79,81,84,88,107,109,110,113,137,138,141,163,166,169,193,194,195,196,199,202,235,249,251,253,254,257,261,278,279,280,282,311, vsvydfeeetfqcelcsytcpRrSnldRhmkshtderphkchlcgrafRtvtLlrnhlnthtgtrphkcpdcdmafvTSgElvRhrrYkhthekpfkcsmcdyasvEvSKlkRhirshtgerpfqcslcsyasrdtYKlkRhmrthsgekpyecyicharftQsgTmkMhilqkhtenvakfhcphcdtviaRKSDlgVhlRkqhsyieqgkkcrycdavfheryaliqhqkshKnekrfkcdqcdyaCrQeRHmiMhkrThtgekpyacshcdktfRQKqLldmhfkryhdpnfvpaafvcskcgktftRrntmarhadnc
interface signature	////RSRRLTSERYESKRYKRQTMRKSDVRKCQRHMTRQKLR

Estimated binding specificities ?

readout + contact

# IC=17.560 IC/col=0.164 n_of_columns=107

specificity:

A |  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  20  15  12  21  30  22  23  42   4   0   0   1   6   0   7   7   2   6  14   8   0  12  24  24  24  24  24  19  22  22   0  16   4  92   6  11  24  24  34  24
C |  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  36  49  12  33  22  27  21  18   2  96   0  92  78  96  74  81   2   6  52   8   0  12  24  24  24  24  24  20  22  20   0  14  81   2  78   9  24  24  20  24
G |  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  20  17  12  21  22  25  21  18  88   0  96   2   6   0   7   4   2  78  14   8  96  60  24  24  24  24  24  38  22  34  96  52   4   1   6   9  24  24  20  24
T |  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  20  15  60  21  22  22  31  18   2   0   0   1   6   0   8   4  90   6  16  72   0  12  24  24  24  24  24  19  30  20   0  14   7   1   6  67  24  24  22  24

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updated Sun Dec 15 16:40:42 2024