8b76_B : 3D-footprint complex

structure name	THE CRYSTAL STRUCTURE OF M644G VARIANT OF DNA POL EPSILON CONTAINING DTTP IN THE POLYMERASE ACTIVE SITE (DNA polymerase epsilon catalytic subunit A)
reference	Johansson et al. 'Nucleic ? ? 2023
source	Saccharomyces cerevisiae
experiment	X-ray (resolution=2.60, R-factor=0.222)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
sequence family	DNA polymerase family B, exonuclease do; DNA polymerase family B 998;
reference complex	4m8o_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8b76_B interface=457,760,763,764,766,902,923, nnyalsaqqllnaskiddidsmmgferyvppqyngrfdakdidqipgrvgwltnmhatlvsqenqgisgvdfyfldeeggsfkstvvydpyffiacndesrvndveelvkkylesclkslqiirkedltmdnhllglqktliklsfvnsnqlfearkllrpilqdnannnvqrniynvdakhliedireydvpyhvrvsidkdirvgkwykvtqqgfiedtrkiafadpvvmafdiettkpplkfpdsavdqimmisymidgegflitnreiisediedfeytpkpeypgfftifnendevallqrffehirdvrptvistfngdffdwpfihnrskihgldmfdeigfapdaegeykssycshmdcfrwvkrdsylpqgsqglkavtqsklgynpieldpelmtpyafekpqhlseysvsdavatyylymkyvhpfifslctiiplnpdetlrkgTgtlcemllmvqayqhnillpnkhtdpierfydghllesetyvgghvesleagvfrsdlknefkidpsaidellqelpealkfsvevenkssvdkvtnfeeiknqitqkllelkennirnelpliyhvdvasgypnimttnrlqpdsikaerdctcarklkwawrgeffpskmdeynmikralqnetfpnknkfskkkvltfdelsyadqvihikkrlteysrkvyhrvkvseivereaivcqrenpfyvdtvksfrdrryefkglaktwkgnlskidpsdkhardeakkmivlydslqlahkVilNSfYgyvmrkgsrwysmemagitcltgatiiqmaralvervgrpleldtdgiwcilpksfpetyfftlengkklylsypcsmlnyrvhqkftnhqyqelkdplnyiyethsentiffevdgpykamilpsskeegkgikKryavfnedgslaelkgfelkRrgelqliknfqsdifkvflegdtlegcysavasvcnrwldvldshglmlededlvslicenrsmsktlkeyegqkstsittarrlgdflgedmvkdkglqckyiisskpfnapvteraipvaifsadipikrsflrrwtldpsledldirtiidwgyyrerlgsaiqkiitipaalqgvsnpvprvehpdwlkrkiat
interface signature	TVNSYKR

Estimated binding specificities ?

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# IC=2.386 IC/col=0.596 n_of_columns=4

specificity:

A |  75  75   7   7
C |   7   7  75   9
G |   7   7   7  73
T |   7   7   7   7

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updated Tue Dec 17 15:40:15 2024