8x21_AB : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE MUTANT Q151M/Y115F/F116Y/L74V:DNA:ETV-TP TERNARY COMPLEX
reference	Hattori et al. 'Sci 14 15742 2024
experiment	X-ray (resolution=2.33, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8x21_A interface=24,61,63,74,76,78,94,157,183,184,265,448, pispietvpvklkpgmdgpkvkqWplteekikalveictemekegkiskigpenpyntpvFaIkkkdstkwrkVvDfRelnkrtqdfwevqlgIphpaglkqkksvtvldvgdafysvpldkdfrkytaftipsinnetpgiryqynvlpmgwkgsPaifqssmtkilepfrkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwgfttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgklNwasqiyagikvrqlskllrgtkaltevvplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmkgahtndvkqlteavqkiatesiviwgktpkfklpiqketweawwteywqatwipewefvntpplvklwyqlekepiigaetfyvdgaanRetklgkagyvtdrgrqkvvpltdttnqktelqaihlalqdsglevnivtdsqyalgiiqaqpdkseselvsqiieqlikkekvylawvpahkgiggneqvdklvs > 8x21_B interface=248, ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkqkksvtvldvgdayfsvpldkdfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgsdleigqhrtkieelrqhllrwggyelhpdkwtvqpivlpekdswtvndiqklvgklnwasQiyagikvrqlskllrgtkaltevvplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmkgahtndvkqlteavqkiatesiviwgktpkfklpiqketweawwteywqatwipewefvntpplvklwy
interface signature	WFIVDRIPYMNR/Q

Estimated binding specificities ?

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# IC=9.337 IC/col=0.283 n_of_columns=33

specificity:

A |   0   0  11   0  24  24  24  24  24  24  24  24  24  24  24   0  24   0  24  24  24  24  24  24  24  24  24  24  24  24  11   0   9
C |   0  96   9  96  24  24  24  24  24  24  24  24  24  24  24   0  24   0  24  24  24  24  24  24  24  24  24  24  24  24   9   0  69
G |   0   0  67   0  24  24  24  24  24  24  24  24  24  24  24   0  24   0  24  24  24  24  24  24  24  24  24  24  24  24  67  96   9
T |  96   0   9   0  24  24  24  24  24  24  24  24  24  24  24  96  24  96  24  24  24  24  24  24  24  24  24  24  24  24   9   0   9

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updated Thu Jan 8 15:35:22 2026