8x21_CD : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE MUTANT Q151M/Y115F/F116Y/L74V:DNA:ETV-TP TERNARY COMPLEX
reference	Hattori et al. 'Sci 14 15742 2024
experiment	X-ray (resolution=2.33, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8x21_C interface=24,61,63,74,76,78,94,157,183,184,265,475,501, pispietvpvklkpgmdgpkvkqWplteekikalveictemekegkiskigpenpyntpvFaIkkkdstkwrkVvDfRelnkrtqdfwevqlgIphpaglkqkksvtvldvgdafysvpldkdfrkytaftipsinnetpgiryqynvlpmgwkgsPaifqssmtkilepfrkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwgfttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgklNwasqiyagikvrqlskllrgtkaltevvplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmkgahtndvkqlteavqkiatesiviwgktpkfklpiqketweawwteywqatwipewefvntpplvklwyqlekepiigaetfyvdgaanretklgkagyvtdrgrqkvvpltdttnQktelqaihlalqdsglevnivtdsqYalgiiqaqpdkseselvsqiieqlikkekvylawvpahkgiggneqvdklvs > 8x21_D interface= ietvpvklkpgmdgpkvkqwpltEekikalveictemekegkiskigpenpyntpvfaikKkDstkwrklvdfReLnKrtqdfwevqlgiphpAglkqkksvtvldvgdayfsvpldkdfrkytaftipsinnetpgiryqynvlpqgwkgspaifQssmtkilepfrkqnpdiviyqymddLYvgsdleigqhrtkieelrqhllrwggyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiyagikvrqlskllrgTkaltevvplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmkgahtndvkqlteavqkiatesiviwgktpkfklpiqketweawwteywqatwipewefvntpplvklwy
interface signature	WFIVDRIPYMNQY/EKDRLKAQLYT

Estimated binding specificities ?

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# IC=9.600 IC/col=0.291 n_of_columns=33

specificity:

A |   0   0   5   0  24  13  24  24  24  24  24  24  24  24  24   3  24  24   5  24  24  24  24  24  24  24  24  24  24  24   3   0   5
C |   0  96   3  96  24  56  24  24  24  24  24  24  24  24  24   3  24  24   3  24  24  24  24  24  24  24  24  24  24  24   5   0  75
G |   0   0  75   0  24  17  24  24  24  24  24  24  24  24  24   3  24  24  85  24  24  24  24  24  24  24  24  24  24  24  85  96  13
T |  96   0  13   0  24  10  24  24  24  24  24  24  24  24  24  87  24  24   3  24  24  24  24  24  24  24  24  24  24  24   3   0   3

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updated Sun Jun 28 01:11:14 2026