8x21_CD : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE MUTANT Q151M/Y115F/F116Y/L74V:DNA:ETV-TP TERNARY COMPLEX
reference	Hattori et al. 'Sci 14 15742 2024
experiment	X-ray (resolution=2.33, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8x21_C interface=24,61,63,74,76,78,94,157,183,184,265,475,501, pispietvpvklkpgmdgpkvkqWplteekikalveictemekegkiskigpenpyntpvFaIkkkdstkwrkVvDfRelnkrtqdfwevqlgIphpaglkqkksvtvldvgdafysvpldkdfrkytaftipsinnetpgiryqynvlpmgwkgsPaifqssmtkilepfrkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwgfttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgklNwasqiyagikvrqlskllrgtkaltevvplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmkgahtndvkqlteavqkiatesiviwgktpkfklpiqketweawwteywqatwipewefvntpplvklwyqlekepiigaetfyvdgaanretklgkagyvtdrgrqkvvpltdttnQktelqaihlalqdsglevnivtdsqYalgiiqaqpdkseselvsqiieqlikkekvylawvpahkgiggneqvdklvs > 8x21_D interface= ietvpvklkpgmdgpkvkqwpltEekikalveictemekegkiskigpenpyntpvfaikKkDstkwrklvdfReLnKrtqdfwevqlgiphpAglkqkksvtvldvgdayfsvpldkdfrkytaftipsinnetpgiryqynvlpqgwkgspaifQssmtkilepfrkqnpdiviyqymddLYvgsdleigqhrtkieelrqhllrwggyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiyagikvrqlskllrgTkaltevvplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmkgahtndvkqlteavqkiatesiviwgktpkfklpiqketweawwteywqatwipewefvntpplvklwy
interface signature	WFIVDRIPYMNQY/EKDRLKAQLYT

Estimated binding specificities ?

contact

# IC=9.691 IC/col=0.294 n_of_columns=33

specificity:

A |   0   0   3   0  24  15  24  24  24  24  24  24  24  24  24   3  24  24   5  24  24  24  24  24  24  24  24  24  24  24   3   0   3
C |   0  96   3  96  24  54  24  24  24  24  24  24  24  24  24   5  24  24   3  24  24  24  24  24  24  24  24  24  24  24   3   0  77
G |   0   0  77   0  24  17  24  24  24  24  24  24  24  24  24   3  24  24  85  24  24  24  24  24  24  24  24  24  24  24  87  96  13
T |  96   0  13   0  24  10  24  24  24  24  24  24  24  24  24  85  24  24   3  24  24  24  24  24  24  24  24  24  24  24   3   0   3

scan!

home
updated Thu Jan 8 15:35:55 2026