8x22_CD : 3D-footprint complex

structure name	HIV-1 REVERSE TRANSCRIPTASE MUTANT Q151M/Y115F/F116Y/L74V:DNA:DGTP TERNARY COMPLEX
reference	Hattori et al. 'Sci 14 15742 2024
experiment	X-ray (resolution=2.31, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
reference complex	7ozw_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8x22_C interface=24,61,63,74,76,78,94,157,183,184,265,448,475,501, pispietvpvklkpgmdgpkvkqWplteekikalveictemekegkiskigpenpyntpvFaIkkkdstkwrkVvDfRelnkrtqdfwevqlgIphpaglkqkksvtvldvgdafysvpldkdfrkytaftipsinnetpgiryqynvlpmgwkgsPaifqssmtkilepfrkqnpdiviyqYMddlyvgsdleigqhrtkieelrqhllrwgfttpdkkhqkeppflwmgyelhpdkwtvqpivlpekdswtvndiqklvgklNwasqiyagikvrqlskllrgtkaltevvplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmkgahtndvkqlteavqkiatesiviwgktpkfklpiqketweawwteywqatwipewefvntpplvklwyqlekepiigaetfyvdgaanRetklgkagyvtdrgrqkvvpltdttnQktelqaihlalqdsglevnivtdsqYalgiiqaqpdkseselvsqiieqlikkekvylawvpahkgiggneqvdklvs > 8x22_D interface= ietvpvklkpgmdgpkvkqwpltEekikalveictemekegkiskigpenpyntpvfaikKkDstkwrklvdfReLnKrtqdfwevqlgiphpAglkqkksvtvldvgdayfsvpldkdfrkytaftipsinnetpgiryqynvlpqgwkgspaifQssmtkilepfrkqnpdiviyqymddLYvgsdleigqhrtkieelrqhllrwggyelhpdkwtvqpivlpekdswtvndiqklvgklnwasqiyagikvrqlskllrgTkaltevvplteeaelelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmkgahtndvkqlteavqkiatesiviwgktpkfklpiqketweawwteywqatwipewefvntpplvklwy
interface signature	WFIVDRIPYMNRQY/EKDRLKAQLYT

Estimated binding specificities ?

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# IC=10.077 IC/col=0.305 n_of_columns=33

specificity:

A |   0   0   6   0  24  24  24  24  24  24  24  24  24  24  24   6  24   0   6  24  24  24  24  24  24  24  24  24  24  24   6   0   6
C |   0  96   6  96  24  24  24  24  24  24  24  24  24  24  24   6  24   0   6  24  24  24  24  24  24  24  24  24  24  24   6   0  78
G |   0   0  78   0  24  24  24  24  24  24  24  24  24  24  24   6  24   0  78  24  24  24  24  24  24  24  24  24  24  24  78  96   6
T |  96   0   6   0  24  24  24  24  24  24  24  24  24  24  24  78  24  96   6  24  24  24  24  24  24  24  24  24  24  24   6   0   6

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updated Thu Jan 8 15:37:02 2026