interface graph thumbnail
legend  pdf

structure nameHUMAN P53 CORE DOMAIN WITH HOT SPOT MUTATION R273C AND SECOND-SITE SUPPRESSOR MUTATION T284R IN SEQUENCE-SPECIFIC COMPLEX WITH DNA
(Cellular tumor antigen p53)
referenceDiskin-Posner et al. 'Nucleic 41 8748 2013
sourceHomo sapiens
experimentX-ray (resolution=1.70, R-factor=0.165)
structural superfamilyp53-like transcription factors;
sequence familyP53 DNAbinding domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKACR

Estimated binding specificities ?

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# IC=2.727 IC/col=0.682 n_of_columns=4 specificity:   
A |  10   1   0  74
C |  23  10  96  10
G |  53  64   0  12
T |  10  21   0   0
scan!

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updated Fri Jan 9 00:45:54 2026