interface graph thumbnail
legend  pdf

structure nameHUMAN TOPOISOMERASE I/DNA COMPLEX
(PROTEIN DNA TOPOISOMERASE I)
referenceChampoux et al. Science 279 1504 1998
sourceHomo sapiens
experimentX-ray (resolution=2.50, R-factor=?)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex1a31_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKYMNKKKTN

Estimated binding specificities ?

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# IC=3.971 IC/col=0.662 n_of_columns=6 specificity:   
A |   0  24  87  43   8   0
C |  96  24   0  26  26   0
G |   0  24   0  17  43   0
T |   0  24   9  10  19  96
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updated Sat Aug 2 00:42:03 2025