interface graph thumbnail
legend  pdf

structure nameHUMAN TOPOISOMERASE I/DNA COMPLEX
(PROTEIN DNA TOPOISOMERASE I)
referenceChampoux et al. Science 279 1504 1998
sourceHomo sapiens
experimentX-ray (resolution=2.50, R-factor=?)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKYMNKKKTN

Estimated binding specificities ?

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# IC=3.800 IC/col=0.633 n_of_columns=6 specificity:   
A |  96   8  18  11  24   0
C |   0  54   0   8  24   0
G |   0  26  26   8  24  96
T |   0   8  52  69  24   0
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updated Mon Dec 16 17:37:50 2024