interface graph thumbnail
legend  pdf

structure nameHUMAN TOPOISOMERASE I/DNA COMPLEX
(PROTEIN DNA TOPOISOMERASE I)
referenceChampoux et al. Science 279 1504 1998
sourceHomo sapiens
experimentX-ray (resolution=2.50, R-factor=?)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex1a31_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKYMNKKKTN

Estimated binding specificities ?

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# IC=3.750 IC/col=0.625 n_of_columns=6 specificity:   
A |  96  19  10   8  24   0
C |   0  34   8   8  24   0
G |   0  26  17   2  24  96
T |   0  17  61  78  24   0
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updated Sun Jun 28 03:15:45 2026