interface graph thumbnail
legend  pdf

structure nameTOPOISOMERASE I/DNA COMPLEX
(TOPOISOMERASE I)
referenceChampoux et al. Science 279 1534 1998
sourceHomo sapiens
experimentX-ray (resolution=2.80, R-factor=0.224)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;Eukaryotic DNA topoisomerase I, dispensable insert domain;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex1a31_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRYMNKKTNN

Estimated binding specificities ?

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# IC=5.035 IC/col=0.839 n_of_columns=6 specificity:   
A |  96   9   7   7  66   0
C |   0  73   8   7  14   0
G |   0   7   0   9   9  96
T |   0   7  81  73   7   0
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updated Sat Aug 2 00:42:20 2025