interface graph thumbnail
legend  pdf

structure nameTOPOISOMERASE I/DNA COMPLEX
(TOPOISOMERASE I)
referenceChampoux et al. Science 279 1534 1998
sourceHomo sapiens
experimentX-ray (resolution=2.80, R-factor=0.224)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;Eukaryotic DNA topoisomerase I, dispensable insert domain;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex1a31_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRYMNKKTNN

Estimated binding specificities ?

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# IC=5.129 IC/col=0.855 n_of_columns=6 specificity:   
A |  96   6   6   6  68   0
C |   0  78   9   6   6   0
G |   0   6   6   6  16  96
T |   0   6  75  78   6   0
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updated Thu Jan 8 17:40:21 2026