1c0w_ABCD : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE COBALT-ACTIVATED DIPHTHERIA TOXIN REPRESSOR- DNA COMPLEX REVEALS A METAL BINDING SH-LIKE DOMAIN
reference	Holmes et al. J.Mol.Biol. 292 653 1999
source	Corynebacterium diphtheriae
experiment	X-ray (resolution=3.20, R-factor=?)
structural superfamily	Iron-dependent repressor protein, dimerization domain;"Winged helix" DNA-binding domain;
reference complex	1ddn_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1c0w_A interface=36,38,39,42,46, kdlvdttemylrtiyeleeegvtplrariaerleqSgPTvsQtvaRmerdglvvvasdrslqmtptgrtlatavmrkhrlaerlltdiigldinkvhdeacrwehvmsdeverrlvkvlkdvsrspfgnpipgldelgvivqineifqvetdqftqlldavellddlahtiri > 1c0w_B interface=36,38,39,41,42, kdlvdttemylrtiyeleeegvtplrariaerleqSgPTvSQtvarmerdglvvvasdrslqmtptgrtlatavmrkhrlaerlltdiigldinkvhdeacrwehvmsdeverrlvkvlkdvsrspfgnpipgldelgvapgtrvidaatsmprkvrivqineifqvetdqftqlldadirvgseveivdrdghitlshngkdvellddlahtirieel > 1c0w_C interface=36,38,39,42,46, kdlvdttemylrtiyeleeegvtplrariaerleqSgPTvsQtvaRmerdglvvvasdrslqmtptgrtlatavmrkhrlaerlltdiigldinkvhdeacrwehvmsdeverrlvkvlkdvsrspfgnpipgldelgvivqineifqvetdqftqlldadirvellddlahtir > 1c0w_D interface=36,38,39,41,42, kdlvdttemylrtiyeleeegvtplrariaerleqSgPTvSQtvarmerdglvvvasdrslqmtptgrtlatavmrkhrlaerlltdiigldinkvhdeacrwehvmsdeverrlvkvlkdvsrspfgnpipgldelgvvqineifqvetdqftqlldadirvvellddlahtir
interface signature	SPTQR/SPTSQ/SPTQR/SPTSQ

Estimated binding specificities ?

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# IC=14.237 IC/col=1.095 n_of_columns=13

specificity:

A |  81   5   0   0  96   0   0   7   0  96   0   5   5
C |   5   5   0   0   0   0   0  79   0   0  96  81   5
G |   5  81  96   0   0  96  91   5   0   0   0   5   5
T |   5   5   0  96   0   0   5   5  96   0   0   5  81

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updated Wed Jun 24 08:54:38 2026