interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
(DNA TOPOISOMERASE I)
referenceChampoux et al. Biochemistry 39 6832 2000
sourceHomo sapiens
experimentX-ray (resolution=2.60, R-factor=?)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex1a31_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRIYMNKDN

Estimated binding specificities ?

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# IC=4.717 IC/col=0.786 n_of_columns=6 specificity:   
A |   0   0   0  60  18   0
C |  96  18   6   6   6   0
G |   0  30  90  12  54   0
T |   0  48   0  18  18  96
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updated Sat Aug 2 00:50:02 2025