interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HUMAN TOPOISOMERASE I DNA COMPLEX
(DNA TOPOISOMERASE I)
referenceChampoux et al. Biochemistry 39 6832 2000
sourceHomo sapiens
experimentX-ray (resolution=2.60, R-factor=?)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex1a31_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRIYMNKDN

Estimated binding specificities ?

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# IC=4.560 IC/col=0.760 n_of_columns=6 specificity:   
A |  96  14   7   0  44   0
C |   0  44  22  96  22   0
G |   0  16   8   0  16  96
T |   0  22  59   0  14   0
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updated Thu Jan 8 17:51:52 2026