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structure namePHOB EFFECTOR DOMAIN IN COMPLEX WITH PHO BOX DNA.
(PHOSPHATE REGULON TRANSCRIPTIONAL REGULATORY PROTEIN)
referenceGomis-Ruth et al. Structure 10 701 2002
sourceESCHERICHIA COLI
experimentX-ray (resolution=2.50, R-factor=0.247)
structural superfamilyC-terminal effector domain of the bipartite response regulators;
sequence familyTranscriptional regulatory protein, C ter;
multimeric complexes1gxp_AB 1gxp_EF 3t72_1Z 3t72_45 3t72_89 3t72_ABq 3t72_EFo 3t72_IJ 3t72_MN 3t72_RS 3t72_VW 3t72_cd 3t72_gh 3t72_kl
redundant complexes2z33 3t72
reference complex2z33_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRTDVRRR

Estimated binding specificities ?

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# IC=7.822 IC/col=0.782 n_of_columns=10 specificity:   
A |   0   0  25   0  24  24  25  96   0  90
C |  96   5  20   0  24  24   5   0  96   0
G |   0   0  15   0  24  24  45   0   0   0
T |   0  91  36  96  24  24  21   0   0   6
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: PHOB
TGTCAPubMed1gxp_A(4.44e-03), 1gxp_AB(4.80e-05), 1gxp_EF(4.44e-05)

Dendrogram of similar interfaces ?

matrix format
  
  --------RTTT--DAVT----RGRG----RA   L                               +-1gxp_A    
                                                          +----------4 
  --------NTVC--ECSTYT--STYC----RA   L                    !          +-5ed4_A    
                                                     +----5 
  --------RG----DTVT----STRG----WT   L               !    !            +6lxn_A    
                                            +--------7    +------------1 
  --------RG----DTVT----ST--RG--RC   L      !        !                 +4nhj_A    
                                            !        ! 
  --------RCTT----TTHT--LA--------   L      !        +-----------------7e1b_B    
                                            !  
  ----------------------------YG--       +-10                          +2heo_D    
                                         !  !        +-----------------3 
  SGQG--YCNC----------------------       !  ! +------8                 +2ve9_C    
                                         !  ! !      ! 
  ------------QTNAST--RGHTNTSTLA--   L   !  ! !      +------------------2hdc_A    
                                         !  +-9 
  --------KGTC--KGTCHT------------   L -11    !                         +4wuh_B    
                                         !    !          +--------------2 
  ----TC--KTTC--KGTCHT--ST--------   L   !    +----------6              +7ve5_B    
                                         !               ! 
  --------SCTA--KTVCHT--KG--------   L   !               +--------------1je8_F    
                                         !  
  ----TTRCECRT--RCQT--------------   L   +----------------------------7kuf_B    
                                       

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updated Thu Sep 12 14:41:48 2024