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structure namePHOB EFFECTOR DOMAIN IN COMPLEX WITH PHO BOX DNA.
(PHOSPHATE REGULON TRANSCRIPTIONAL REGULATORY PROTEIN)
referenceGomis-Ruth et al. Structure 10 701 2002
sourceESCHERICHIA COLI
experimentX-ray (resolution=2.50, R-factor=0.247)
structural superfamilyC-terminal effector domain of the bipartite response regulators;
sequence familyTranscriptional regulatory protein, C ter;
redundant complexes2z33 3t72
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRTDVRRR

Estimated binding specificities ?

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# IC=7.089 IC/col=0.709 n_of_columns=10 specificity:   
A |   6   3  13   0  24  24  18  96   0  84
C |  84   3  18   0  24  24   5   0  96   3
G |   3   6  14   0  24  24  59   0   0   3
T |   3  84  51  96  24  24  14   0   0   6
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: PHOB
TGTCAPubMed1gxp_A(4.44e-03), 1gxp_AB(4.80e-05), 1gxp_EF(4.44e-05)

Dendrogram of similar interfaces ?

matrix format
  
  --------RTTT--DAVT----RGRG----RA   L                               +-1gxp_A    
                                                          +----------4 
  --------NTVC--ECSTYT--STYC----RA   L                    !          +-5ed4_A    
                                                     +----5 
  --------RG----DTVT----STRG----WT   L               !    !            +6lxn_A    
                                            +--------7    +------------1 
  --------RG----DTVT----ST--RG--RC   L      !        !                 +4nhj_A    
                                            !        ! 
  --------RCTT----TTHT--LA--------   L      !        +-----------------7e1b_B    
                                            !  
  ----------------------------YG--       +-10                          +2heo_D    
                                         !  !        +-----------------3 
  SGQG--YCNC----------------------       !  ! +------8                 +2ve9_C    
                                         !  ! !      ! 
  ------------QTNAST--RGHTNTSTLA--   L   !  ! !      +------------------2hdc_A    
                                         !  +-9 
  --------KGTC--KGTCHT------------   L -11    !                         +4wuh_B    
                                         !    !          +--------------2 
  ----TC--KTTC--KGTCHT--ST--------   L   !    +----------6              +7ve5_B    
                                         !               ! 
  --------SCTA--KTVCHT--KG--------   L   !               +--------------1je8_F    
                                         !  
  ----TTRCECRT--RCQT--------------   L   +----------------------------7kuf_B    
                                       

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updated Mon Dec 16 17:51:55 2024