1hlz_AB : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA- BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT
reference	Rastinejad et al.
source	Homo sapiens
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	1a6y_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1hlz_A interface=22,25,29,30,79, vllckvcgdvasgfhygvlacEgcKgffRRsiqqniqykrclknencsivrinrnrcqqcrfkkclsvgmsrdavrfgRip > 1hlz_B interface=24,27,31,32,79,81, gmvllckvcgdvasgfhygvlacEgcKgffRRsiqqniqykrclknencsivrinrnrcqqcrfkkclsvgmsrdavrFgR
interface signature	EKRRR/EKRRFR

Estimated binding specificities ?

readout + contact

# IC=14.427 IC/col=0.801 n_of_columns=18

specificity:

A |  77  90  11  24  11   0   0   3   0  92  24  24  24   0   0   7   0  90
C |   7   3  67  24   5   0   0   7  96   3  24  24  24   0   0   7  96   3
G |   3   3  11  24   7  96  96   3   0   0  24  24  24  96  96   7   0   3
T |   9   0   7  24  73   0   0  83   0   1  24  24  24   0   0  75   0   0

scan!

home
updated Sun Jan 4 21:23:30 2026