1hlz_AB : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA- BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT
reference	Rastinejad et al.
source	Homo sapiens
experiment	X-ray (resolution=2.80, R-factor=?)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
reference complex	1a6y_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1hlz_A interface=22,25,29,30,79, vllckvcgdvasgfhygvlacEgcKgffRRsiqqniqykrclknencsivrinrnrcqqcrfkkclsvgmsrdavrfgRip > 1hlz_B interface=24,27,31,32,79,81, gmvllckvcgdvasgfhygvlacEgcKgffRRsiqqniqykrclknencsivrinrnrcqqcrfkkclsvgmsrdavrFgR
interface signature	EKRRR/EKRRFR

Estimated binding specificities ?

readout + contact

# IC=14.354 IC/col=0.797 n_of_columns=18

specificity:

A |  71  88  14  24   5   0   0   3   0  92  24  24  24   0   0   9   0  90
C |   7   5  68  24   7   0   0   7  96   0  24  24  24   0   0   7  96   0
G |  11   3   7  24   3  96  96   5   0   4  24  24  24  96  96   7   0   3
T |   7   0   7  24  81   0   0  81   0   0  24  24  24   0   0  73   0   3

scan!

home
updated Wed Jun 24 09:27:33 2026