1ic8_AB : 3D-footprint complex

structure name	HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT
reference	Dhe-Paganon et al. Mol.Cell 10 1129 2002
source	Homo sapiens
experiment	X-ray (resolution=2.60, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1ic8_A interface=54,55,56,57,59,60,67,159,160,164,167, kelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgtPmktqkraalytwyvrkqrevaqqftharnrfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea > 1ic8_B interface=56,57,58,59,61,62,68,69,98,160,161,164,165,168, ilkelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTPmktqkraalytwyvrkqrevaqqfthrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfANrrKeeafr
interface signature	NQSHSQPYNNK/NQSHSQTPRYNANK

Estimated binding specificities ?

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# IC=17.390 IC/col=1.023 n_of_columns=17

specificity:

A |   3   0   0   0  89  21   0   1  91   0   4  96  96   6   0  76  70
C |   0   0  19   0   1   2   0   0   0   0  16   0   0  76  96   6  10
G |  93  96   2  96   4  66   0   2   0   0  10   0   0   8   0   8  10
T |   0   0  75   0   2   7  96  93   5  96  66   0   0   6   0   6   6

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updated Tue Jul 29 14:56:08 2025