1ic8_AB : 3D-footprint complex

structure name	HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT
reference	Dhe-Paganon et al. Mol.Cell 10 1129 2002
source	Homo sapiens
experiment	X-ray (resolution=2.60, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1ic8_A interface=54,55,56,57,59,60,67,159,160,164,167, kelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgtPmktqkraalytwyvrkqrevaqqftharnrfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea > 1ic8_B interface=56,57,58,59,61,62,68,69,98,160,161,164,165,168, ilkelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTPmktqkraalytwyvrkqrevaqqfthrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfANrrKeeafr
interface signature	NQSHSQPYNNK/NQSHSQTPRYNANK

Estimated binding specificities ?

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# IC=17.245 IC/col=1.014 n_of_columns=17

specificity:

A |   2   0   0   0  89  31   0   1  89   0   6  96  96   4   0  78  78
C |   0   0  32   0   0   6   0   0   1   0  11   0   0  78  96   5   6
G |  93  96   2  96   5  55   0   4   0   0  17   0   0  10   0   2   8
T |   1   0  62   0   2   4  96  91   6  96  62   0   0   4   0  11   4

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updated Wed Jun 24 09:29:27 2026