1ic8_AB : 3D-footprint complex

structure name	HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT
reference	Dhe-Paganon et al. Mol.Cell 10 1129 2002
source	Homo sapiens
experiment	X-ray (resolution=2.60, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1ic8_A interface=54,55,56,57,59,60,67,159,160,164,167, kelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgtPmktqkraalytwyvrkqrevaqqftharnrfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea > 1ic8_B interface=56,57,58,59,61,62,68,69,98,160,161,164,165,168, ilkelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTPmktqkraalytwyvrkqrevaqqfthrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfANrrKeeafr
interface signature	NQSHSQPYNNK/NQSHSQTPRYNANK

Estimated binding specificities ?

readout + contact

# IC=17.731 IC/col=1.043 n_of_columns=17

specificity:

A |   5   5   0   5   0   0  64  96   5  96  96   5   2   0  74   0   0
C |  10   5   0   5   0   0  13   0   1   0   0  69   9  96   0  96  96
G |   9   9  96  80   0   0  14   0   0   0   0   2   0   0  21   0   0
T |  72  77   0   6  96  96   5   0  90   0   0  20  85   0   1   0   0

scan!

home
updated Sun Jan 4 21:25:24 2026