1ic8_AB : 3D-footprint complex

structure name	HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT
reference	Dhe-Paganon et al. Mol.Cell 10 1129 2002
source	Homo sapiens
experiment	X-ray (resolution=2.60, R-factor=?)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1ic8_A interface=54,55,56,57,59,60,67,159,160,164,167, kelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgtPmktqkraalytwyvrkqrevaqqftharnrfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea > 1ic8_B interface=56,57,58,59,61,62,68,69,98,160,161,164,165,168, ilkelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTPmktqkraalytwyvrkqrevaqqfthrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfANrrKeeafr
interface signature	NQSHSQPYNNK/NQSHSQTPRYNANK

Estimated binding specificities ?

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# IC=21.329 IC/col=1.123 n_of_columns=19

specificity:

A |   9   0   0   0   0   0  96  96   0  96  96   0   0   0  96   0   9  24   9
C |   9   0   0   0   0   0   0   0   0   0   0   0   0  96   0  96  67  24   9
G |  11   0  96  96   0   0   0   0   0   0   0   0   0   0   0   0  11  24  69
T |  67  96   0   0  96  96   0   0  96   0   0  96  96   0   0   0   9  24   9

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updated Fri Dec 13 09:20:35 2024