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structure nameDNA BINDING DOMAIN OF HNF-1A BOUND TO P2-HNF4A PROMOTER DNA
(Hepatocyte nuclear factor 1-alpha)
referenceMyllykoski et al. 'JCI 9 ? 2024
sourceHomo sapiens
experimentX-ray (resolution=2.30, R-factor=0.216)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyHepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain;
multimeric complexes1ic8_AB 8pi7_AB 8pi8_AB 8pi9_AB 8pia_AB
redundant complexes1ic8_A 8pi7_A 8pi9_B 8pia_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNQSHSQTPRYNNK

Estimated binding specificities ?

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# IC=12.445 IC/col=0.957 n_of_columns=13 specificity:   
A |   5   0  96   5   0   5  24   5   5  80  96   0   0
C |   5   0   0  80   0  80  24   6   6   6   0  96   0
G |   5   0   0   6   0   5  24   5   5   5   0   0  96
T |  81  96   0   5  96   6  24  80  80   5   0   0   0
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updated Wed Dec 18 19:13:28 2024