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structure nameHUMAN TOPOISOMERASE I (TOPO70) DOUBLE MUTANT K532R/Y723F
(DNA topoisomerase I)
referenceChampoux et al. J.Biol.Chem. 279 2984 2004
sourceHomo sapiens
experimentX-ray (resolution=3.13, R-factor=0.280)
structural superfamilyEukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment;DNA breaking-rejoining enzymes;Eukaryotic DNA topoisomerase I, dispensable insert domain;
sequence familyEukaryotic DNA topoisomerase I, DNA bind; Eukaryotic DNA topoisomerase I, catalyti;
reference complex1a31_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRYMNKRN

Estimated binding specificities ?

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# IC=6.672 IC/col=0.953 n_of_columns=7 specificity:   
A |   0   9  96  96   9   0   9
C |  96  11   0   0  11   0  69
G |   0   9   0   0  67   0   9
T |   0  67   0   0   9  96   9
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updated Thu Sep 12 15:24:15 2024